ArticleJournal of cellular physiology2019
Investigation of indolamine 2, 3 dioxygenase (IDO-1) gene expression by real-time PCR among patients with lung cancer.
Article in Journal of cellular physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Feruloylated Arabinoxylan From Maize Bran Induces Cell Death in HCT 116 Colon Cancer Cells By the Cross-Talk of Apoptosis, Cell Survival, and Autophagy Pathways.Applied biochemistry and biotechnology · 2026Article
- LRP6 aggravates proliferation, invasion, and immunosuppression in diffuse large B-cell lymphoma: a novel prognostic marker and therapy target.Annals of hematology · 2026Article
- Integrative Analysis of Neutrophil-Associated Genes Reveals Prognostic Significance and Immune Microenvironment Modulation in Cervical Cancer.Biomedicines · 2025Article
- Indoleamine 2,3-dioxygenase-1 expression in non-small-cell lung cancer: analyses of prevalence, clinical correlations and prognostic impact in 2 large patient cohorts.Frontiers in immunology · 2025Article
- Calcium Channel Blocker Lacidipine Promotes Antitumor Immunity by Reprogramming Tryptophan Metabolism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Prognostic and immune correlation of IDO1 promoter methylation in breast cancer.Scientific reports · 2024Article
- IDO1 plays a tumor-promoting role via MDM2-mediated suppression of the p53 pathway in diffuse large B-cell lymphoma.Cell death & disease · 2022Article
- Mechanism of miR-760 Reversing Lung Cancer Immune Escape by Downregulating IDO1 and Eliminating Regulatory T Cells Based on Mathematical Biology.Computational and mathematical methods in medicine · 2022Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of this study was to evaluate the expression of IDO-1 gene and cancerous grades of non-small cell lung cancer (NSCLC) and its subclasses among patients with lung cancer using real-time polymerase chain reaction (PCR). MATERIALS AND
methodsA total of 35 clinical samples were collected from patients with NSCLC. To evaluate the IDO-1 gene after the extraction of RNA and complementary DNA (cDNA) synthesis using real-time PCR, the expression of the gene was investigated. The western blot analysis method was used for protein expression.
resultsThe highest grade, IIIa grade included six patients (17.1%). Approximately 74% of adenocarcinoma cases were in T-categories of lung cancer and 25% of patients in IIIa grade. Patients in the IIA and IIB categories belong to the SCC subclass. Results showed that the expression of INDO 5.22 fold gene was more common in patients with lung cancer than NSCLC. Protein expression in western blot analysis in patients compared with normal 3.22 fold change increased.
conclusionThe evidence shows that IDO-1 is a key parameter that inhibits antitumor immune responses in humans. This study has added interesting data to the IDO community for analyzing the expression of cancerous human cancer cells and cancer tissue in humans. The results showed that IDO-1 not only participates in the process of escape from tumor immunity but can also contribute to the safety of the pretumor area. A wide variety of observed IDO-1 expression values among patients may present serious barriers to the clinical performance of anti- IDO strategies at present.
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