ArticleJournal of clinical monitoring and computing2019
Non-sinusoidal waves in the EEG and their simulated effect on anaesthetic quantitative EEG monitors.
Article in Journal of clinical monitoring and computing, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- SedlineAnimals : an open access journal from MDPI · 2023Article
- A Waveform-Independent Measure of Recurrent Neural Activity.Frontiers in neuroinformatics · 2022Article
- Revealing the Dynamic Nature of Amplitude Modulated Neural Entrainment With Holo-Hilbert Spectral Analysis.Frontiers in neuroscience · 2021Article
- End of year summary 2019: anaesthesia and airway management.Journal of clinical monitoring and computing · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The effect of anaesthetic drugs on the cortex are commonly estimated from the electroencephalogram (EEG) by quantitative EEG monitors such as the Bispectral Index (BIS). These monitors use ratios of high to low frequency power which assumes that each neurological process contributes a unique frequency pattern. However, recent research of the effect of deep brain stimulation on EEG beta oscillations suggests that wave shape, a non-sinusoidal feature that is only measurable in the time-domain, can change the frequency 'signature' of a neurological rhythmical process by the inclusion or removal of harmonic frequencies. If wave shape variations are present in the EEG of anaesthetised patients, then quantitative EEG monitors likely overestimate the anaesthetic drug effect. The purpose of this paper is to investigate alpha-wave shape in the EEG of anaesthetised patients and demonstrate the effect of wave shape on the frequency ratios that are commonly utilised in the BIS quantitative EEG monitor. EEG data, demographic information, and surgery details were collected prospectively from 305 patients undergoing a general anaesthetic for elective surgery. Alpha-wave shape was categorised by triangularity of the EEG extrema, a measure of how peaked (towards a sawtooth wave) or flat (towards a square wave) the extremum was. The alpha-wave was then artificially modified to either a sawtooth wave or square wave, and BetaRatio and PowerFastSlow metrics calculated. Age was found to be the only significant predictor of alpha wave triangularity. The artificially modified square-alpha waves increased the power in the frequency spectrum at 26 Hz by 1-5 dB, and increased the BetaRatio by 0.7. The alpha-wave of anaesthetised patients contains non-sinusoidal components which likely impact depth of anaesthesia calculations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.