ArticleInternational urology and nephrology2019
Whole mount histopathological correlation with prostate MRI in Grade I and II prostatectomy patients.
Article in International urology and nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Exploring the potential ofProstate international · 2024Article
- Integrating biomarkers and multi-parametric MRI to provide enhanced clinical diagnosis for prostate cancer.Frontiers in urology · 2023Review
- Prostate zones and cancer: lost in transition?Nature reviews. Urology · 2022Review
- Artificial Intelligence Combined With Big Data to Predict Lymph Node Involvement in Prostate Cancer: A Population-Based Study.Frontiers in oncology · 2021Article
- Article
- Observed racial disparity in the negative predictive value of multi-parametric MRI for the diagnosis for prostate cancer.International urology and nephrology · 2019Article
- Mri-based cancer lesion analysis with 3d printed patient specific prostate cutting guides.American journal of clinical and experimental urology · 2019Article
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8 authors.
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Abstract
backgroundMultiparametric magnetic resonance imaging (mpMRI) is increasingly used in detection and surveillance of prostate cancer. However, the co-localization of lower grade lesions between mpMRI and histopathologic specimen has not been well established.
objectiveWe aim to determine the factors on final histopathological exam that correlate to tumor visibility for Grade I and II disease on mpMRI.
methodsFifty-five patients who underwent radical prostatectomy from July 2014 to June 2016 were analyzed for the study. Of the sample of 55 patients, 18 were found to have Gleason score (GS) of 3 + 3 or 3 + 4 disease, and then were re-reviewed and annotated by a pathologist. Lesion diameter, area, and distance from the prostate capsule were measured. The annotated lesions were co-localized to the MRI report.
resultsOf the 184 lesions identified on the whole mount histopathologic slides, 106 (57.6%), 62 (33.7%), 14 (7.6%), and 2 (1.1%) of the lesions had a GS of 3 + 3, 3 + 4, 4 + 3, and 4 + 4, respectively. On analysis, 27.3% (24/88) of GS 6 (< 1.5 cm in size), and 88.9% (16/18) of GS 6 (> 1.5 cm in size) were identified (p < 0.001). Additionally, when assessing lesion proximity to the prostatic capsule, 46.1% (41/89) of lesions closer (≤ 0.05 cm), and 30.5% (29/95) of lesions further (> 0.05 cm) from the capsule were visualized.
conclusionLesion diameter, area, and capsule proximity correlated with MRI visibility. Further studies are encouraged to validate the findings of our study.
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