ReviewCurrent osteoporosis reports2019
Mechanisms Underlying Normal Fracture Healing and Risk Factors for Delayed Healing.
Review in Current osteoporosis reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Effects of pulsed electromagnetic fields on bone fractures: a systematic review update.European journal of physical and rehabilitation medicine · 2024Pooled it
- Secondary Carpal Tunnel Release After Surgical Fixation of the Distal Radius: A Case-Control Study.Hand (New York, N.Y.) · 2026Article
- Knowledge, Attitudes, and Practices Regarding Postoperative Management Among Patients with Fractures: A Cross-Sectional Study.Patient preference and adherence · 2026Article
- Fu's subcutaneous needling-assisted conservative treatment for distal radius fracture healing: protocol for a randomized controlled trial.Journal of orthopaedic surgery and research · 2025Article
- Surgical management and outcomes of pure sacroiliac joint dislocations: A systematic review.Journal of orthopaedics · 2025Review
- Construction of dynamic ceRNA regulatory networks in osteogenesis during fracture healing based on transcriptomic analysis.Scientific reports · 2025Article
- Bone Mineral Density and Intermuscular Fat Derived from Computed Tomography Images Using Artificial Intelligence Are Associated with Fracture Healing.Bioengineering (Basel, Switzerland) · 2025Article
- Serum miR-519d-3p and BMP2: potential early diagnostic markers and their mechanism in delayed fracture healing.Journal of orthopaedic surgery and research · 2025Article
- Computational evaluation of the biomechanical effects of position changes in the femoral neck system on Pauwels type III femoral neck fractures: an in silico study.Frontiers in bioengineering and biotechnology · 2025Article
- Silencing p75NTR regulates osteogenic differentiation and angiogenesis of BMSCs to enhance bone healing in fractured rats.Journal of orthopaedic surgery and research · 2024Article
- Identification of the miRNA-mRNA regulatory network in a mouse model of early fracture.Frontiers in genetics · 2024Article
- 3WJ RNA Nanoparticles-Aptamer Functionalized Exosomes From M2 Macrophages Target BMSCs to Promote the Healing of Bone Fractures.Stem cells translational medicine · 2023Article
- Identification of the miRNAome in human fracture callus and nonunion tissues.Journal of orthopaedic translation · 2023Article
- Deciphering the protective effect of Buzhong Yiqi Decoction on osteoporotic fracture through network pharmacology and experimental validation.Journal of orthopaedic surgery and research · 2023Article
- The Role of Sympathetic Nerves in Osteoporosis: A Narrative Review.Biomedicines · 2022Review
- Alcohol-induced inhibition of bone formation and neovascularization contributes to the failure of fracture healing via the miR-19a-3p/FOXF2 axis.Bone & joint research · 2022Article
- The Human Gut Microbiota: A Key Mediator of Osteoporosis and Osteogenesis.International journal of molecular sciences · 2021Review
- Finite Element Analysis of Fracture Fixation.Current osteoporosis reports · 2021Review
- Exosomes: A Friend or Foe for Osteoporotic Fracture?Frontiers in endocrinology · 2021Review
- Beneficial role of microRNA-328-3p in fracture healing by enhancing osteoblastic viability through the PTEN/PI3K/AKT pathway.Experimental and therapeutic medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewSubstantial advances have been made in understanding the biological basis of fracture healing. Yet, it is unclear whether the presence of osteoporosis or prior or current osteoporosis therapy influences the healing process or is associated with impaired healing. This review discusses the normal process of fracture healing and the role of osteoporosis and patient-specific factors in relation to fracture repair. RECENT
findingsThe definitive association of osteoporosis to impaired fracture healing remains inconclusive because of limited evidence addressing this point. eStudies testing anabolic agents in preclinical models of ovariectomized animals with induced fractures have produced mostly positive findings showing enhanced fracture repair. Prospective human clinical trials, although few in number and limited in design and to testing only one anabolic agent, have similarly yielded modestly favorable results. Interest is high for exploring currently available osteoporosis therapies for efficacy in fracture repair. Definitive data supporting their efficacy are essential in achieving approval for this indication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.