ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2019
Long-Term Endocrine and Exocrine Insufficiency After Pancreatectomy.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 6 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Incidence and Determinants of Steatotic Liver Disease after Pancreaticoduodenectomy: A Systematic Review and Meta-Analysis.Journal of hepato-biliary-pancreatic sciences · 2026Pooled it
- European guidelines for the diagnosis and treatment of pancreatic exocrine insufficiency: UEG, EPC, EDS, ESPEN, ESPGHAN, ESDO, and ESPCG evidence-based recommendations.United European gastroenterology journal · 2025Guideline
- Exocrine Pancreatic Insufficiency After Pancreatectomy for Malignancy: Systematic Review and Optimal Management Recommendations.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Pooled it
- Comparison of Outcomes of Enucleation vs. Standard Surgical Resection for Pancreatic Neoplasms: A Systematic Review and Meta-Analysis.Frontiers in surgery · 2021Pooled it
- Central pancreatectomy: a comprehensive, up-to-date meta-analysis.Langenbeck's archives of surgery · 2019Pooled it
- Risk factors for exocrine pancreatic insufficiency after pancreatic surgery: a systematic review and meta-analysis.Canadian journal of surgery. Journal canadien de chirurgiePooled it
- Progress, challenges, and future directions of pancreatic cancer surveillance in high-risk populations.Communications medicine · 2026Review
- Pancreaticoduodenectomy is associated with more progressive bone mineral density loss than distal pancreatectomy.Surgery today · 2026Article
- Decision Modeling to Guide Management of Pancreatic IPMNs: Immediate Surgery or Initial Surveillance?Annals of surgical oncology · 2026Article
- Shared Decision-Making in IPMN of the Pancreas: A Framework for Surgical Decisions Under Uncertainty.Annals of surgical oncology · 2026Review
- Total pancreas-preserving pancreatic injury-site jejunostomy for traumatic pancreatic head injury with main pancreatic duct transection: feasibility and decision algorithm.Trauma surgery & acute care open · 2026Article
- Postoperative Blood Glucose Spikes Predict Morbidity After Pancreatoduodenectomy.Journal of diabetes research · 2026Observational
- Sex hormone receptor signaling networks drive pancreatic solid-pseudopapillary neoplasm pathogenesis and therapy.Discover oncology · 2025Review
- Comprehensive Insights into Solid Pseudopapillary Neoplasms of the Pancreas: A Single Center Experience of 64 Surgical Cases.Indian journal of surgical oncology · 2025Article
- Review
- Enucleation of Pancreatic Lesions: The Outcomes and Experiences from Two Centers.Annals of surgical oncology · 2025Article
- Review
- Nutritional benefits of pancreas-sparing total duodenectomy for severe duodenal polyposis in patients with familial adenomatous polyposis.Annals of gastroenterological surgery · 2025Article
- Review
- Portuguese Pancreatic Club Perspectives on Endoscopic Ultrasound-Guided and Surgical Treatment of Pancreatic Neuroendocrine Tumors.GE Portuguese journal of gastroenterology · 2024Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
purposeTo identify peri-operative risk factors and time to onset of pancreatic endocrine/exocrine insufficiency.
methodsWe retrospectively analyzed a single institutional series of patients who underwent pancreaticoduodenectomy (PD) or distal pancreatectomy (DP) between 2000 and 2015. Endocrine/exocrine insufficiencies were defined as need for new pharmacologic intervention. Cox proportional modeling was used to identify peri-operative variables to determine their impact on post-operative pancreatic insufficiency.
resultsA total of 1717 patient records were analyzed (75.47% PD, 24.53% DP) at median follow-up 17.88 months. Average age was 62.62 years, 51.78% were male, and surgery was for malignancy in 74.35% of patients. Post-operative endocrine insufficiency was present in 20.15% (n = 346). Male gender (p = 0.015), increased body mass index (BMI) (p < 0.001), tobacco use (p = 0.011), family history of diabetes (DM) (p < 0.001), personal history of DM (p ≤ 0.001), and DP (p ≤ 0.001) were correlated with increased risk. Mean time to onset was 20.80 ± 33.60 (IQR: 0.49-28.37) months. Post-operative exocrine insufficiency was present in 36.23% (n = 622). Race (p = 0.014), lower BMI (p < 0.001), family history of DM (p = 0.007), steatorrhea (p < 0.001), elevated pre-operative bilirubin (p = 0.019), and PD (p ≤ 0.001) were correlated with increased risk. Mean time to onset was 14.20 ± 26.90 (IQR: 0.89-12.69) months.
conclusionsIn this large series of pancreatectomy patients, 20.15% and 36.23% of patients developed post-operative endocrine and exocrine insufficiency at a mean time to onset of 20.80 and 14.20 months, respectively. Patients should be educated regarding post-resection insufficiencies and providers should have heightened awareness long-term.
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