Evidence map›Paper›PMID 30671778›Full record

ArticleJournal of neurovirology2019

Vitamin D is not associated with HIV-associated neurocognitive disorder in Rakai, Uganda.

Deanna Saylor, Gertrude Nakigozi, Carlos A Pardo, Alice Kisakye, Anupama Kumar, Noeline Nakasujja, Kevin R Robertson, Ronald H Gray, Maria J Wawer, Ned Sacktor

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurovirology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Deanna SaylorDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. deanna@jhmi.edu.ORCID 0000-0002-9297-0244
Gertrude NakigoziRakai Health Sciences Program, Kalisizo, Uganda.
Carlos A PardoDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Alice KisakyeRakai Health Sciences Program, Kalisizo, Uganda.
Anupama KumarDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Noeline NakasujjaDepartment of Psychiatry, Makerere University, Kampala, Uganda.
Kevin R RobertsonDepartment of Neurology, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
Ronald H GrayDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Maria J WawerDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Ned SacktorDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
Therapeutic CoreP30MH075673 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Leah Helane Rubin · 2006 to 2026
$33.2M
Research Education Program for Residents and Fellows in Neurology - PorrasR25NS065729 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HILLIS, ARGYE E. · 2009 to 2024
$3.3M
Neurologic Sequelae of HIV Subtype A and D Infection and ART Rakai UgandaR01MH099733 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SACKTOR, NED C, WAWER, MARIA J · 2013 to 2017
$3.0M
Translational Research in Neuro-AIDS and Mental HealthR25MH080661 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MCARTHUR, JUSTIN CHARLES. · 2007 to 2019
$2.9M
Mental Health and Cognition in HIV Infection in Rakai UgandaR01MH120693 · NIMH · JOHNS HOPKINS UNIVERSITY · PI PAUL, ROBERT HARRIS, RUBIN, LEAH HELANE · 2019 to 2023
$2.9M
NIAID NIH HHS P30 AI094189NIMH NIH HHS P30 MH075673NIMH NIH HHS R01 MH099733NIMH NIH HHS R01 MH120693NIMH NIH HHS R25 MH080661NINDS NIH HHS L30 NS088658NINDS NIH HHS R25 NS065729
6 · The paper itself

Abstract

We investigated whether vitamin D is associated with HIV-associated neurocognitive disorder (HAND). HIV-infected (HIV+) antiretroviral therapy (ART)-naïve adults in rural Uganda underwent a neurocognitive battery for determination of HAND stage at baseline and after 2 years. Baseline serum 25-hydroxyvitamin D (25OH-D) and serum and cerebrospinal fluids (CSF) vitamin D-binding protein (VDBP) were obtained. Of the 399 participants, 4% (n = 16) were vitamin D deficient (25OH-D < 20 ng/mL). There was no association between 25OH-D, serum or CSF VDBP, and HAND stage at baseline or follow-up. Future studies in a population with higher levels of vitamin D deficiency may be warranted.

Indexed as

AIDS Dementia ComplexVitamin D-Binding ProteinAdultFemaleHumansMaleUgandaVitamin D25-hydroxyvitamin DVitamin DVitamin D-Binding ProteinAfricaEpidemiologyHIVHIV-associated neurocognitive disorderVitamin D

Identifiers

PMID30671778
PMCPMC6635069

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.