Evidence map›Paper›PMID 30671741›Full record

ArticleMolecular imaging and biology2019

PET/CT Imaging of NSCLC with a α

Paul Flechsig, Thomas Lindner, Anastasia Loktev, Saskia Roesch, Walter Mier, Max Sauter, Michael Meister, Christel Herold-Mende, Uwe Haberkorn, Annette Altmann

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05835570 (A Single-arm, Open-label, Single-center Clinical Study to the Evaluation of Integrin αvβ6-targeted Positron Emission Tomography), which is not on this map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05835570 recruitingnot on this mapstarted 2023, after this paper: background citation

A Single-arm, Open-label, Single-center Clinical Study to the Evaluation of Integrin αvβ6-targeted Positron Emission Tomography (PET) for Malignant Tumors

TypeobservationalSponsorZhongnan HospitalRan2023 to 2025Enrolled200ConditionsMalignant Neoplasm, PET/CT, Non-Small Cell Lung Cancer, Breast Cancer, MetastaticArmsPET/CT scans
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Comparison of theMolecular therapy. Oncology · 2026
    Article
  3. Synthesis and preclinical development of a novelEJNMMI radiopharmacy and chemistry · 2026
    Article
  4. Review
  5. PET/CT imaging of esophageal cancer targeting tumor cell specific αvβ6-integrin expression.European journal of nuclear medicine and molecular imaging · 2025
    Article
  6. Integrin αvβ6-Targeted PET/CT Imaging of Non-Small Cell Lung Cancer with [Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Observational
  7. Article
  8. Article
  9. Review
  10. Fully-automated production of [Frontiers in oncology · 2024
    Article
  11. Radionuclide-based theranostics - a promising strategy for lung cancer.European journal of nuclear medicine and molecular imaging · 2023
    Review
  12. Preclinical Evaluation ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  13. Review
  14. Frontiers in oncology · 2023
    Article
  15. Pilot-phase PET/CT study targeting integrin αEuropean journal of nuclear medicine and molecular imaging · 2022
    Article
  16. Article
  17. Review
  18. Review
  19. Recent Applications of Retro-Inverso Peptides.International journal of molecular sciences · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Paul FlechsigDepartment of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany. paul.flechsig@med.uni-heidelberg.de.
Thomas LindnerDepartment of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany.
Anastasia LoktevClinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Saskia RoeschDivision of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.
Walter MierDepartment of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany.
Max SauterDepartment of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany.
Michael MeisterDepartment of Thoracic Oncology, University Hospital Heidelberg, Heidelberg, Germany.
Christel Herold-MendeDivision of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.
Uwe HaberkornDepartment of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany.
Annette AltmannDepartment of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany.
University Hospital Heidelberg · DEHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTargeted therapies are regarded as promising approaches to increase 5-year survival rate of non-small cell lung cancer (NSCLC) patients. Here, we investigated the clinical value of the α

methodsAffinity and binding properties of [

resultsIn vitro experiments revealed a significant time-dependent SFITGv6 binding of up to 33 % to α

conclusionsEven if SFITGv6 demonstrates excellent affinity and specificity for α

Indexed as

Positron Emission Tomography Computed TomographyAnimalsAntigens, NeoplasmCarcinoma, Non-Small-Cell LungCell Line, TumorFluorodeoxyglucose F18Gallium RadioisotopesHumansIntegrinsLung NeoplasmsMice, Inbred BALB CMice, NudePeptide FragmentsTissue DistributionAntigens, NeoplasmFluorodeoxyglucose F18Gallium-68Gallium Radioisotopesintegrin alphavbeta6IntegrinsPeptide FragmentsSFITGv6 peptide[18F] FDG[68Ga]SFITGv6Non-small cell lung cancerPeptidePET/CT scanαvβ6 integrin

Identifiers

PMID30671741
OpenAlexW2919869382

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.