Evidence map›Paper›PMID 30671716›Full record

ArticleJournal of youth and adolescence2019

Identifying Critical Points of Trajectories of Depressive Symptoms from Childhood to Young Adulthood.

Alex S F Kwong, David Manley, Nicholas J Timpson, Rebecca M Pearson, Jon Heron, Hannah Sallis, Evie Stergiakouli, Oliver S P Davis, George Leckie

Abstract read
In one paragraph

Article in Journal of youth and adolescence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  17. Depression Symptom Trajectories in Mothers With the FMR1 Premutation Vary by CGG Repeat Length: A Longitudinal Study of 73 Women Spanning 20-75 Years of Age.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2025
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30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alex S F KwongSchool of Geographical Sciences, University of Bristol, University Road, Bristol, BS8 1SS, UK. Alex.Kwong@Bristol.ac.uk.ORCID http://orcid.org/0000-0003-1953-2771
David ManleySchool of Geographical Sciences, University of Bristol, University Road, Bristol, BS8 1SS, UK.
Nicholas J TimpsonMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Rebecca M PearsonMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Jon HeronMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Hannah SallisMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Evie StergiakouliMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Oliver S P DavisMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
George LeckieCentre for Multilevel Modelling, University of Bristol, Bristol, UK.

Funding

Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_12013/3Medical Research Council MR/L010305/1Medical Research Council MR/M006727/1Wellcome Trust
6 · The paper itself

Abstract

Depression is a common mental illness and research has focused on late childhood and adolescence in an attempt to prevent or reduce later psychopathology and/or social impairments. It is important to establish and study population-averaged trajectories of depressive symptoms across adolescence as this could characterise specific changes in populations and help identify critical points to intervene with treatment. Multilevel growth-curve models were used to explore adolescent trajectories of depressive symptoms in 9301 individuals (57% female) from the Avon Longitudinal Study of Parents and Children, a UK based pregnancy cohort. Trajectories of depressive symptoms were constructed for males and females using the short mood and feelings questionnaire over 8 occasions, between 10 and 22 years old. Critical points of development such as age of peak velocity for depressive symptoms (the age at which depressive symptoms increase most rapidly) and the age of maximum depressive symptoms were also derived. The results suggested that from similar initial levels of depressive symptoms at age 11, females on average experienced steeper increases in depressive symptoms than males over their teenage and adolescent years until around the age of 20 when levels of depressive symptoms plateaued and started to decrease for both sexes. Females on average also had an earlier age of peak velocity of depressive symptoms that occurred at 13.5 years, compared to males who on average had an age of peak velocity at 16 years old. Evidence was less clear for a difference between the ages of maximum depressive symptoms which were on average 19.6 years for females and 20.4 for males. Identifying critical periods for different population subgroups may provide useful knowledge for treating and preventing depression and could be tailored to be time specific for certain groups. Possible explanations and recommendations are discussed.

Indexed as

AdolescentAdultChildDepressionFemaleGrowth ChartsHumansLongitudinal StudiesMalePregnancySurveys and QuestionnairesUnited KingdomYoung AdultALSPACCritical pointsDepressive symptomsMultilevel growth-curve modellingTrajectories

Identifiers

PMID30671716
PMCPMC6441403

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.