Evidence map›Paper›PMID 30671709›Full record

ArticleJournal of neuro-oncology2019

Effect of health disparities on overall survival of patients with glioblastoma.

Jacob J Mandel, Michael Youssef, Jooyeon Nam, Akash J Patel, Ali Jalali, Ethan B Ludmir, Diane Liu, Jimin Wu, Georgina Armstrong, Jason Huse and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neuro-oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jacob J MandelDepartment of Neurology and Neurosurgery, Baylor College of Medicine, One Baylor Plaza, MS NB302, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0001-5916-5668
Michael YoussefDepartment of Neurology and Neurosurgery, Baylor College of Medicine, One Baylor Plaza, MS NB302, Houston, TX, 77030, USA.
Jooyeon NamDepartment of Neurological Sciences, Rush Medical Center, 1725 W. Harrison, St. Suite 1010, Chicago, IL, USA.
Akash J PatelDepartment of Neurology and Neurosurgery, Baylor College of Medicine, One Baylor Plaza, MS NB302, Houston, TX, 77030, USA.
Ali JalaliDepartment of Neurology and Neurosurgery, Baylor College of Medicine, One Baylor Plaza, MS NB302, Houston, TX, 77030, USA.
Ethan B LudmirDivision of Radiation Oncology - Unit 1422, The University of Texas MD Anderson Cancer Center, 1400 Pressler St, Houston, TX, FCT6.5000, 77030, USA.
Diane LiuDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, P. O. Box 301402, Houston, TX, 1409, 77230-1402, USA.
Jimin WuDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, P. O. Box 301402, Houston, TX, 1409, 77230-1402, USA.
Georgina ArmstrongDepartment of Medicine, Baylor College of Medicine, One Baylor Plaza, MS NB305, Houston, TX, 77030, USA.
Jason HuseDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, 2130 West Holcombe Boulevard, Suite 910, Houston, TX, 77030, USA.
Melissa BondyDepartment of Medicine, Baylor College of Medicine, One Baylor Plaza, MS NB305, Houston, TX, 77030, USA.
John F de GrootDepartment of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Unit 431, 1515 Holcombe Blvd, Houston, TX, 77030-4009, USA. jdegroot@mdanderson.org.

Funding

Genetic Epidemiology of Glioma International ConsortiumR01CA119215 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BONDY, MELISSA L. · 2006 to 2010
$11.9M
6 · The paper itself

Abstract

backgroundExamine the potential effects of health disparities in survival of glioblastoma (GB) patients.

methodsWe conducted a retrospective chart review of newly diagnosed GB patients from 2000 to 2015 at a free standing dedicated cancer center (MD Anderson Cancer Center-MDACC) and a safety net county hospital (Ben Taub General Hospital-BT) located in Houston, Texas. We obtained demographics, insurance status, extent of resection, treatments, and other known prognostic variables (Karnofsky Score-KPS) to evaluate their role on overall GB survival (OS).

resultsWe identified 1073 GB patients consisting of 177 from BT and 896 from MDACC. We found significant differences by ethnicity, insurance status, KPS at diagnosis, extent of resection, and percentage of patients receiving standard of care (SOC) between the two centers. OS was 1.64 years for MDACC patients and 1.24 years for BT patients (p < 0.0176). Only 81 (45.8%) BT patients received SOC compared to 577 (64%) of MDACC patients (p < 0.0001). However, there was no significant difference in OS for patients who received SOC, 1.84 years for MDACC patients and 1.99 years for BT patients (p < 0.4787). Of the 96 BT patients who did not receive SOC, 29 (30%) had KPS less than 70 at time of diagnosis and 77 (80%) lacked insurance.

conclusionsGB patients treated at a safety net county hospital had similar OS compared to a free standing comprehensive cancer center when receiving SOC. County hospital patients had poorer KPS at diagnosis and were often lacking health insurance affecting their ability to receive SOC.

Indexed as

Healthcare DisparitiesAdolescentAdultAgedAged, 80 and overBrain NeoplasmsFemaleGlioblastomaHumansInsurance, HealthKarnofsky Performance StatusMaleMiddle AgedPrognosisRacial GroupsRetrospective StudiesGlioblastomaHealth disparitiesInsuranceOverall survivalRace

Identifiers

PMID30671709

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.