Evidence map›Paper›PMID 30671638›Full record

ArticleWorld journal of urology2019

Focal laser ablation as clinical treatment of prostate cancer: report from a Delphi consensus project.

A van Luijtelaar, B M Greenwood, H U Ahmed, A B Barqawi, E Barret, J G R Bomers, M A Brausi, P L Choyke, M R Cooperberg, S Eggener and 28 more

Registry-linked trialAbstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of urology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04045756 (Short-term Efficacy of Transperineal Laser Ablation), which is not on this map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04045756 naunknown statusnot on this map

Short-term Efficacy of Transperineal Laser Ablation (TPLA) With Image Fusion and Multi-parametric (mpMRI) Follow-up in Focal Low-intermediate Risk Prostate Cancer: Interventional Pilot Study

TypeinterventionalSponsorUniversity of Rome Tor VergataRan2019 to 2024Enrolled50ConditionsProstate CancerArmsProcedure/Surgery: Transperineal Focal Laser Ablation (TPLA)
3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Surveillance after Focal Therapy - a Comprehensive Review.Prostate cancer and prostatic diseases · 2025
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Motorized template for MRI-guided focal cryoablation of prostate cancer.IEEE transactions on medical robotics and bionics · 2023
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

A van LuijtelaarDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands. Annemarijke.vanluijtelaar@radboudumc.nl.ORCID http://orcid.org/0000-0002-9383-3233
B M GreenwoodDesert Medical Imaging, Indian Wells, CA, USA.
H U AhmedDepartment of Surgery, Imperial College London, London, UK.
A B BarqawiDivision of Urology, Department of Surgery, University of Colorado Denver School of Medicine, Aurora, CO, USA.
E BarretL'Institut Mutualiste Montsouris, Paris Descartes University, Paris, France.
J G R BomersDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
M A BrausiDepartment of Urology, AUSL Modena, Modena, Italy.
P L ChoykeMolecular Imaging Program, National Cancer Institute, Bethesda, MD, USA.
M R CooperbergUniversity of California San Francisco, San Francisco, CA, USA.
S EggenerDepartment of Urology, University of Chicago Medical Center, Chicago, IL, USA.
J F FellerDesert Medical Imaging, Indian Wells, CA, USA.
F FrauscherMedizinische Universität Innsbruck, Innsbruck, Austria.
A K GeorgeUrologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
R G HindleyDepartment of Urology, Basingstoke Hospital, Hampshire Hospitals NHS Foundation Trust, Basingstoke, UK.
S F M JenniskensDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
L KlotzSunnybrook Health Sciences Centre, Toronto, ON, Canada.
G KovacsInterdisciplinary Brachytherapy Unit, University of Lübeck, Lübeck, Germany.
U LindnerDepartment of Urology, Kaplan Medical Center, Rehovot, Israel.
S LoebDepartment of Urology and Population Health, New York University and Manhattan Veterans Affairs Medical Center, New York, NY, USA.
D J MargolisDepartment of Radiology, Ronald Reagan-UCLA Medical Center, Los Angeles, CA, USA.
L S MarksDepartment of Urology, University of California-Los Angeles, Los Angeles, CA, USA.
S MayDesert Medical Imaging, Indian Wells, CA, USA.
T D McclureDepartment of Urology, New York Presbyterian-Weill Cornell Medical College, New York, NY, USA.
R MontironiSection of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy.
S G NourDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA.
A OtoDepartment of Radiology, University of Chicago, Chicago, IL, USA.
T J PolascikDepartment of Surgery, Duke University Medical Center, Durham, NC, USA.
A R RastinehadDepartment of Urology, Mount Sinai, New York, NY, USA.
T M De ReykeDepartment of Urology, Amsterdam UMC, Amsterdam, The Netherlands.
J S ReijnenDepartment of Radiology, Sørlandet Hospital, Kristiansand, Norway.
J J M C H de la RosetteDepartment of Urology, Istanbul Medipol University, Istanbul, Turkey.
J P M SedelaarDepartment of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.
D S SperlingSperling Prostate Center, Manhattan, NY, USA.
E M WalserDepartment of Radiology, University of Texas Medical Branch, Galveston, TX, USA.
J F WardDivision of Surgery, Department of Urology, University of Texas, Houston, TX, USA.
A VillersDepartment of Urology, Lille University Medical Center, Lille, France.
S GhaiUniversity of Toronto, Toronto, ON, Canada.
J J FüttererDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Funding

Prostate Cancer ImagingZIABC010655 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHOYKE, PETER L · 2009 to 2025
$49.2M
6 · The paper itself

Abstract

purposeTo define the role of focal laser ablation (FLA) as clinical treatment of prostate cancer (PCa) using the Delphi consensus method.

methodsA panel of international experts in the field of focal therapy (FT) in PCa conducted a collaborative consensus project using the Delphi method. Experts were invited to online questionnaires focusing on patient selection and treatment of PCa with FLA during four subsequent rounds. After each round, outcomes were displayed, and questionnaires were modified based on the comments provided by panelists. Results were finalized and discussed during face-to-face meetings.

resultsThirty-seven experts agreed to participate, and consensus was achieved on 39/43 topics. Clinically significant PCa (csPCa) was defined as any volume Grade Group 2 [Gleason score (GS) 3+4]. Focal therapy was specified as treatment of all csPCa and can be considered primary treatment as an alternative to radical treatment in carefully selected patients. In patients with intermediate-risk PCa (GS 3+4) as well as patients with MRI-visible and biopsy-confirmed local recurrence, FLA is optimal for targeted ablation of a specific magnetic resonance imaging (MRI)-visible focus. However, FLA should not be applied to candidates for active surveillance and close follow-up is required. Suitability for FLA is based on tumor volume, location to vital structures, GS, MRI-visibility, and biopsy confirmation.

conclusionFocal laser ablation is a promising technique for treatment of clinically localized PCa and should ideally be performed within approved clinical trials. So far, only few studies have reported on FLA and further validation with longer follow-up is mandatory before widespread clinical implementation is justified.

Indexed as

Laser TherapyDelphi TechniqueHumansMalePractice Guidelines as TopicProstatectomyProstatic NeoplasmsConsensusDelphiFocal laser ablationLaser focal therapyProstate cancer

Identifiers

PMID30671638
PMCPMC6763411

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.