Evidence map›Paper›PMID 30671600›Full record

ArticleSocial psychiatry and psychiatric epidemiology2019

Psychotic experiences and mood episodes predict each other bidirectionally: a 6-year follow-up study in a community-based population.

Umut Kırlı, Tolga Binbay, Marjan Drukker, Jim van Os, Köksal Alptekin, Bülent Kayahan, Hayriye Elbi

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In one paragraph

Article in Social psychiatry and psychiatric epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Umut KırlıPsychiatry Unit, Van Education and Research Hospital, Van, Turkey.
Tolga BinbayDepartment of Psychiatry, Faculty of Medicine, Dokuz Eylul University, 35340, Izmir, Turkey. tolgabinbay@deu.edu.tr.ORCID http://orcid.org/0000-0001-6030-6798
Marjan DrukkerDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), European Graduate School of Neuroscience (EURON), Maastricht University Medical Centre, Maastricht, The Netherlands.
Jim van OsDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), European Graduate School of Neuroscience (EURON), Maastricht University Medical Centre, Maastricht, The Netherlands.
Köksal AlptekinDepartment of Psychiatry, Faculty of Medicine, Dokuz Eylul University, 35340, Izmir, Turkey.
Bülent KayahanDepartment of Psychiatry, Faculty of Medicine, Ege University, Izmir, Turkey.
Hayriye ElbiDepartment of Psychiatry, Faculty of Medicine, Ege University, Izmir, Turkey.
Dokuz Eylül University · TREge University · TRMaastricht University Medical Centre · NLKing's College London · GB

Funding

Türkiye Bilimsel ve Teknolojik Araştirma Kurumu 107S053Türkiye Bilimsel ve Teknolojik Araştirma Kurumu 112S476
6 · The paper itself

Abstract

backgroundPsychotic experiences (PEs) are not exclusive to psychotic disorders and highly correlated with mood episodes. In this representative general population-based study, longitudinal bidirectional associations between the extended psychosis phenotype and mood episodes were investigated, accounting for other possible causes.

methodsHouseholds were contacted in a multistage clustered probability sampling frame covering 11 districts and 302 neighbourhoods at baseline (n = 4011) and at 6-year follow-up (n = 2185). Participants were interviewed with the relevant sections of the composite international diagnostic interview both at baseline and at follow-up. Sociodemographic, familial and environmental risk factors associated with the extended psychosis phenotype and mood episodes were assessed. Logistic regression and cross-lagged panel correlation models were used for the associations between the extended psychosis phenotype and mood episodes.

resultsPEs were associated with subsequent depressive and manic episodes. There was bidirectionality in that mood episodes were associated with subsequent PEs, and PEs were associated with subsequent mood episodes. The associations occurred in a sub-additive pattern. There were substantial synchronous and cross-lagged correlations between these psychopathology domains, with reciprocally similar cross-lagged correlations. Familial risk and adverse life events were associated with both psychopathology domains, whereas some sociodemographic risk factors and alcohol/cannabis use were associated with only one domain.

conclusionThe sub-additive bidirectional associations between PEs and mood episodes over time and the similarity of cross-lagged correlations are suggestive of mutually causal connections between affective and psychotic domains of psychopathology.

Indexed as

AdultAffectAgedBipolar DisorderComorbidityDepressionDepressive DisorderFemaleFollow-Up StudiesHumansMaleMiddle AgedPsychotic DisordersRisk FactorsYoung AdultBidirectionalityDepressionHypomaniaManiaPsychotic experiences

Identifiers

PMID30671600
OpenAlexW2914388954

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.