Evidence map›Paper›PMID 30671449›Full record

ArticleBioMed research international2018

C-Type Natriuretic Peptide Ameliorates Lipopolysaccharide-Induced Cardiac Dysfunction in Rats with Pulmonary Arterial Hypertension.

Xiaowei Gao, Maoen Zhu, Yanan Cao, Yue Yang, Zhi Ye, Fan Zhang, Qulian Guo, Yonggang Peng, E Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 75% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Xiaowei GaoDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Maoen ZhuDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yanan CaoDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yue YangDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhi YeDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Fan ZhangDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Qulian GuoDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yonggang PengDepartment of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida, USA.
E WangDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID 0000-0001-9463-9769
Central South University · CNUniversity of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipopolysaccharide induces rapid deterioration of cardiac function in rats with pulmonary arterial hypertension. It was desired to investigate if this cardiac dysfunction could be treated by C-type natriuretic peptide. Rat pulmonary arterial hypertension was induced by intraperitoneal injection of monocrotaline. Hemodynamics and cardiac function were measured by pressure-volume (P-V) catheter before and after the rats were treated with lipopolysaccharide and C-type natriuretic peptide. Cyclic guanosine 3',5'-monophosphate (cGMP) level was determined by enzyme-linked immunosorbent assay analysis. After the rats were injected with low-dose lipopolysaccharide, they experienced left ventricle systolic function deterioration. Administration of C-type natriuretic peptide improved hemodynamics and left ventricle systolic function. cGMP level was elevated after C-type natriuretic peptide treatment. C-type natriuretic peptide could ameliorate lipopolysaccharide-induced cardiac dysfunction and restore hemodynamic deterioration in rats with pulmonary arterial hypertension.

Indexed as

AnimalsCyclic GMPHeart DiseasesHeart VentriclesHemodynamicsHypertension, PulmonaryLipopolysaccharidesMaleMonocrotalineNatriuretic Peptide, C-TypePulmonary ArteryRatsRats, Sprague-DawleyCyclic GMPLipopolysaccharidesMonocrotalineNatriuretic Peptide, C-Type

Identifiers

PMID30671449
PMCPMC6317089
OpenAlexW2904873649

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.