ArticleJournal of oral microbiology2019
Metagenome sequencing-based strain-level and functional characterization of supragingival microbiome associated with dental caries in children.
Article in Journal of oral microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Meta-Analysis Using NGS Data: TheFrontiers in oral health · 2021Pooled it
- Association between red biofluorescence and microbial dysbiosis in cariogenic biofilms: an in vitro study.Scientific reports · 2026Article
- Microbiome in adult severe caries and cross-kingdom biofilms validation.Clinical oral investigations · 2026Article
- Mapping the oral microbiome in children with oral diseases using next-generation sequencing: a systematic review.Journal of oral microbiology · 2026Review
- TSLC: differential abundance analysis method for identifying biologically relevant known microbes.Bioinformatics advances · 2026Article
- Feasibility of salivary lipid screening for caries biomarkers in young adults.BMC oral health · 2025Article
- Diabetes alters the supragingival microbiome through plasma-to-saliva migration of glucose and fructose.Microbiome · 2025Article
- Evaluating microbial regulation as a preventive strategy for radiation-related caries: A review.Head & face medicine · 2025Review
- The salivary virome during childhood dental caries.mSphere · 2025Article
- Polymicrobial detection and salivary metabolomics of children with early childhood caries.PeerJ · 2025Article
- The Oral Microbiome: A Key Determinant of Oral Health.Advances in experimental medicine and biology · 2025Review
- Exploring the influence of psychological factors on the comorbidity of dental caries and obesity in adolescents from the perspective of the oral-gut-brain axis.Frontiers in cellular and infection microbiology · 2025Article
- Microbiome variability and role ofJournal of oral microbiology · 2025Article
- Novel potential biomarkers for predicting childhood caries via metagenomic analysis.Frontiers in cellular and infection microbiology · 2025Article
- Oral Microbiome Dynamics in Treated Childhood Caries: A Comparative Study.Life (Basel, Switzerland) · 2024Article
- Extracellular Phosphate Modulation and Polyphosphate Accumulation byDentistry journal · 2024Article
- Impact of cell lysis treatment before saliva metagenomic DNA extraction on the oral microbiome and the associated resistome.Clinical and experimental dental research · 2024Article
- Review
- Findings and methodologies in oral phageome research: a systematic review.Journal of oral microbiology · 2024Review
- Effect of 15 days -6° head-down bed rest on microbial communities of supragingival plaque in young men.Frontiers in microbiology · 2024Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies of the microbiome associated with dental caries have largely relied on 16S rRNA sequence analysis, which is associated with PCR biases, low taxonomic resolution, and inability to accurately study functions. Here, we employed whole metagenome shotgun sequencing, coupled with high-resolution analysis algorithm, to analyze supragingival microbiomes from 30 children with or without dental caries. A total of 726 bacterial strains belonging to 406 species, in addition to 34 bacteriophages were identified. A core bacteriome was identified at the species and strain levels. Species of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.