Evidence map›Paper›PMID 30671059›Full record

ArticleFrontiers in immunology2018

Diversity of Epigenetic Features of the Inactive X-Chromosome in NK Cells, Dendritic Cells, and Macrophages.

Camille M Syrett, Vishal Sindhava, Isabel Sierra, Aimee H Dubin, Michael Atchison, Montserrat C Anguera

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 52 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. The Impact of Menopause on Autoimmune and Rheumatic Diseases.Clinical reviews in allergy & immunology · 2025
    Review
  8. Article
  9. Sex differences in disease: sex chromosome and immunity.Journal of translational medicine · 2024
    Review
  10. Review
  11. Article
  12. Article
  13. The conneXion between sex and immune responses.Nature reviews. Immunology · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Pain mechanisms in the transgender individual: a review.Frontiers in pain research (Lausanne, Switzerland) · 2024
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Camille M SyrettDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Vishal SindhavaDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Isabel SierraDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Aimee H DubinDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Michael AtchisonDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Montserrat C AngueraDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States.
University of Pennsylvania · US

Funding

TRAINING PROGRAM IN CELL AND MOLECULAR BIOLOGYT32GM007229 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BARTOLOMEI, MARISA S. · 1985 to 2023
$14.0M
Control of B cell Development by YY1R01AI079002 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ATCHISON, MICHAEL LEE · 2010 to 2020
$4.3M
Graduate Training in Developmental BiologyT32HD083185 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI Michael Granato, Foteini Mourkioti · 2015 to 2026
$4.0M
Training in Sex and Gender Differences Research to Improve Women's HealthK12HD085848 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI OQUENDO, MARIA A · 2015 to 2019
$2.2M
DEVELOPMENTAL CONTROL OF IMMUNOGLOBULIN TRANSCRIPTIONR01GM042415 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI ATCHISON, MICHAEL L. · 1989 to 2005
$1.7M
The role of YY1 in constitutive and inducible DNA loop formationR01GM111384 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI ATCHISON, MICHAEL LEE · 2014 to 2017
$1.2M
Expression of X-linked autoimmunity genes in B cells during female-biased autoimmunityR21AI124084 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ANGUERA, MONTSERRAT C · 2017 to 2018
$443k
Maintenance of X-chromosome inactivation during B cell developmentF31GM123604 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI SYRETT, CAMILLE MARIE · 2017 to 2018
$68k
NIAID NIH HHS R01 AI079002NIAID NIH HHS R21 AI124084NICHD NIH HHS K12 HD085848NICHD NIH HHS T32 HD083185NIGMS NIH HHS F31 GM123604NIGMS NIH HHS R01 GM042415NIGMS NIH HHS R01 GM111384NIGMS NIH HHS T32 GM007229
6 · The paper itself

Abstract

In females, the long non-coding RNA Xist drives X-chromosome Inactivation (XCI) to equalize X-linked gene dosage between sexes. Unlike other somatic cells, dynamic regulation of Xist RNA and heterochromatin marks on the inactive X (Xi) in female lymphocytes results in biallelic expression of some X-linked genes, including

Indexed as

Epigenesis, GeneticGenetic VariationAnalysis of VarianceAnimalsCell NucleusDendritic CellsDosage Compensation, GeneticFemaleGene Expression RegulationGenes, X-LinkedHeterochromatinKiller Cells, NaturalMacrophagesMaleMembrane GlycoproteinsMiceHeterochromatinMembrane GlycoproteinsRNA, Long NoncodingTlr7 protein, mouseToll-Like Receptor 7XIST non-coding RNAinterferon alphalong non-coding RNAmacrophagesNK cellsplasmacytoid dendritic cellssex differencesX-chromosome inactivationXist RNA

Identifiers

PMID30671059
PMCPMC6331414
OpenAlexW2909113491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.