Evidence map›Paper›PMID 30670978›Full record

ArticleFrontiers in physiology2018

Upregulation of AT

Liping Jiang, Xuan Zhou, Hongyu Yang, Ruijuan Guan, Yanlei Xin, Jijiang Wang, Linlin Shen, Danian Zhu, Shulan Ma, Jin Wang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Reactive oxygen species in hypertension.Nature reviews. Cardiology · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Oxidative Stress and Hypertension.Circulation research · 2021
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Liping JiangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Xuan ZhouDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Hongyu YangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Ruijuan GuanDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Yanlei XinDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Jijiang WangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Linlin ShenDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Danian ZhuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Shulan MaTraining Center of Medical Experiments, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Jin WangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study examined whether angiotensin II (Ang II) mediates the pressor effect through nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-derived reactive oxygen species (ROS)-mitogen-activated protein kinase (MAPK) signaling in the glutamatergic neurons of the rostral ventrolateral medulla (RVLM) in stress-induced hypertensive rats (SIHR). The SIHR model was established using electric foot-shocks combined with noises for 15 days. We observed that Ang II type 1 receptor (AT

Indexed as

angiotensin II type 1 receptorglutamatergic neuronsNAPDH oxidase-ROS-SAPK/JNK signalingrostral ventrolateral medullastress-induced hypertension

Identifiers

PMID30670978
PMCPMC6331519
OpenAlexW2908921447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.