Evidence map›Paper›PMID 30670928›Full record

ArticleMediators of inflammation2018

Pharmacological Inhibition of Caspase-1 Ameliorates Cisplatin-Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation in Mice.

Jung-Yeon Kim, Jae-Hyung Park, Kiryeong Kim, Jungmin Jo, Jaechan Leem, Kwan-Kyu Park

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jung-Yeon KimDepartment of Immunology, School of Medicine, Catholic University of Daegu, Daegu 42472, Republic of Korea.ORCID 0000-0001-7229-1466
Jae-Hyung ParkDepartment of Physiology, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea.ORCID 0000-0002-3549-5977
Kiryeong KimDepartment of Physiology, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea.
Jungmin JoDepartment of Hematology-Oncology, Inje University Seoul Paik Hospital, Seoul 04551, Republic of Korea.ORCID 0000-0002-9322-7540
Jaechan LeemDepartment of Immunology, School of Medicine, Catholic University of Daegu, Daegu 42472, Republic of Korea.ORCID 0000-0003-2329-4374
Kwan-Kyu ParkDepartment of Pathology, School of Medicine, Catholic University of Daegu, Daegu 42472, Republic of Korea.ORCID 0000-0002-5317-750X
Daegu Catholic University · KRKeimyung University · KRInje University Seoul Paik Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Caspase-1 is a proinflammatory caspase responsible for the proteolytic conversion of the precursor forms of interleukin-1

Indexed as

AnimalsApoptosisBlotting, WesternCaspase 1Cell Cycle CheckpointsCisplatinImmunohistochemistryInflammationIn Situ Nick-End LabelingKidneyMaleMiceMice, Inbred C57BLOxidative StressReverse Transcriptase Polymerase Chain ReactionCaspase 1Cisplatin

Identifiers

PMID30670928
PMCPMC6323438
OpenAlexW2906043130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.