Evidence map›Paper›PMID 30670897›Full record

ArticleCanadian journal of veterinary research = Revue canadienne de recherche veterinaire2019

Cochleosaccular (Scheibe) dysplasia in dogs: A temporal bone study.

Nevra Keskin, Hasan Albasan, Irem Gul Sancak, Michael M Paparella, Sebahattin Cureoglu

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Nevra KeskinDepartment of Internal Medicine (Keskin, Albasan) and Department of Surgery (Sancak), Faculty of Veterinary Medicine, University of Ankara, Ankara, Turkey; Department of Otolaryngology, Head and Neck Surgery, School of Medicine, University of Minnesota, Lions Research Building, Room 210, Mayo Mail Code 2873, 2001 6th Street SE, Minneapolis, Minnesota 55455, USA (Keskin, Albasan, Sancak, Cureoglu); Paparella Ear Head & Neck Institute, Minneapolis, Minnesota, USA (Paparella); Department of Otolaryngology, Massachusetts Eye and Ear Infirmary (Mini-fellowship), Harvard University, Boston, Massachusetts, USA (Keskin).
Hasan AlbasanDepartment of Internal Medicine (Keskin, Albasan) and Department of Surgery (Sancak), Faculty of Veterinary Medicine, University of Ankara, Ankara, Turkey; Department of Otolaryngology, Head and Neck Surgery, School of Medicine, University of Minnesota, Lions Research Building, Room 210, Mayo Mail Code 2873, 2001 6th Street SE, Minneapolis, Minnesota 55455, USA (Keskin, Albasan, Sancak, Cureoglu); Paparella Ear Head & Neck Institute, Minneapolis, Minnesota, USA (Paparella); Department of Otolaryngology, Massachusetts Eye and Ear Infirmary (Mini-fellowship), Harvard University, Boston, Massachusetts, USA (Keskin).
Irem Gul SancakDepartment of Internal Medicine (Keskin, Albasan) and Department of Surgery (Sancak), Faculty of Veterinary Medicine, University of Ankara, Ankara, Turkey; Department of Otolaryngology, Head and Neck Surgery, School of Medicine, University of Minnesota, Lions Research Building, Room 210, Mayo Mail Code 2873, 2001 6th Street SE, Minneapolis, Minnesota 55455, USA (Keskin, Albasan, Sancak, Cureoglu); Paparella Ear Head & Neck Institute, Minneapolis, Minnesota, USA (Paparella); Department of Otolaryngology, Massachusetts Eye and Ear Infirmary (Mini-fellowship), Harvard University, Boston, Massachusetts, USA (Keskin).
Michael M PaparellaDepartment of Internal Medicine (Keskin, Albasan) and Department of Surgery (Sancak), Faculty of Veterinary Medicine, University of Ankara, Ankara, Turkey; Department of Otolaryngology, Head and Neck Surgery, School of Medicine, University of Minnesota, Lions Research Building, Room 210, Mayo Mail Code 2873, 2001 6th Street SE, Minneapolis, Minnesota 55455, USA (Keskin, Albasan, Sancak, Cureoglu); Paparella Ear Head & Neck Institute, Minneapolis, Minnesota, USA (Paparella); Department of Otolaryngology, Massachusetts Eye and Ear Infirmary (Mini-fellowship), Harvard University, Boston, Massachusetts, USA (Keskin).
Sebahattin CureogluDepartment of Internal Medicine (Keskin, Albasan) and Department of Surgery (Sancak), Faculty of Veterinary Medicine, University of Ankara, Ankara, Turkey; Department of Otolaryngology, Head and Neck Surgery, School of Medicine, University of Minnesota, Lions Research Building, Room 210, Mayo Mail Code 2873, 2001 6th Street SE, Minneapolis, Minnesota 55455, USA (Keskin, Albasan, Sancak, Cureoglu); Paparella Ear Head & Neck Institute, Minneapolis, Minnesota, USA (Paparella); Department of Otolaryngology, Massachusetts Eye and Ear Infirmary (Mini-fellowship), Harvard University, Boston, Massachusetts, USA (Keskin).
Ankara University · TRPulp and Paper Research Institute · SKUniversity of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to evaluate any otopathologic changes in temporal bone specimens from dogs with deafness related to cochleosaccular (Scheibe) dysplasia (CSD). We used the canine temporal bone collections of the Otopathology Laboratory at the University of Minnesota and of the Massachusetts Eye and Ear Infirmary at Harvard University in Boston. Our morphometric analysis included measuring the areas of the stria vascularis and the spiral ligament and counting the number of spiral ganglion cells. In addition, we noted the presence of the organ of Corti and cochlear hair cells, assessed the location of Reissner's membrane and the saccular membrane, and counted the number of both Type I and Type II vestibular hair cells in the macule of the saccule and vestibular ganglion cells. In the group of specimens from dogs with cochleosaccular dysplasia, we observed generalized degeneration in the cochlea and a significantly decreased number of Type I and Type II vestibular hair cells and vestibular ganglion cells. As hereditary deafness is presently untreatable with known therapeutic methods, dogs with cochleosaccular dysplasia should not be considered for breeding. Future therapeutic approaches, such as stem cell therapies, should be designed to target all the elements of the cochlea in addition to the saccule as it was found that both are affected in dogs with CSD.

Indexed as

AnimalsCochleaDog DiseasesDogsHearing Loss, SensorineuralRetinal Ganglion CellsTemporal Bone

Identifiers

PMID30670897
PMCPMC6318820
OpenAlexW2982881483

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.