Evidence map›Paper›PMID 30670698›Full record

ArticleCell death & disease2019

Eukaryotic initiation factor 5B (eIF5B) provides a critical cell survival switch to glioblastoma cells via regulation of apoptosis.

Joseph A Ross, Keiran Vanden Dungen, Kamiko R Bressler, Mikayla Fredriksen, Divya Khandige Sharma, Nirujah Balasingam, Nehal Thakor

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

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  13. Editorial: RNA machines.Frontiers in genetics · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Joseph A RossDepartment of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive W, Lethbridge, AB, T1K 3M4, Canada.
Keiran Vanden DungenDepartment of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive W, Lethbridge, AB, T1K 3M4, Canada.
Kamiko R BresslerDepartment of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive W, Lethbridge, AB, T1K 3M4, Canada.
Mikayla FredriksenDepartment of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive W, Lethbridge, AB, T1K 3M4, Canada.
Divya Khandige SharmaDepartment of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive W, Lethbridge, AB, T1K 3M4, Canada.
Nirujah BalasingamDepartment of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive W, Lethbridge, AB, T1K 3M4, Canada.
Nehal ThakorDepartment of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive W, Lethbridge, AB, T1K 3M4, Canada. nthakor@uleth.ca.
University of Lethbridge · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physiological stress conditions attenuate global mRNA translation via modifications of key eukaryotic initiation factors. However, non-canonical translation initiation mechanisms allow cap-independent translation of certain mRNAs. We have previously demonstrated that eIF5B promotes cap-independent translation of the mRNA encoding the antiapoptotic factor, XIAP, during cellular stress. Here, we show that depletion of eIF5B sensitizes glioblastoma multiforme cells to TRAIL-induced apoptosis by a pathway involving caspases-8, -9, and -7, with no significant effect on cell cycle progression. eIF5B promotes evasion of apoptosis by promoting the translation of several IRES-containing mRNAs, encoding the antiapoptotic proteins XIAP, Bcl-xL, cIAP1, and c-FLIP

Indexed as

Apoptosisbcl-X ProteinCell Line, TumorCell SurvivalCyclin-Dependent Kinase Inhibitor p21Drug Resistance, NeoplasmEukaryotic Initiation FactorsGlioblastomaHEK293 CellsHumansInhibitor of Apoptosis ProteinsNF-E2-Related Factor 2Recombinant ProteinsRNA, MessengerRNA, Small InterferingTNF-Related Apoptosis-Inducing LigandBCL2L1 protein, humanbcl-X ProteinCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21eukaryotic initiation factor-5BEukaryotic Initiation FactorsInhibitor of Apoptosis ProteinsNFE2L2 protein, humanNF-E2-Related Factor 2Recombinant ProteinsRNA, MessengerRNA, Small InterferingTNF-Related Apoptosis-Inducing LigandTNFSF10 protein, humanXIAP protein, humanX-Linked Inhibitor of Apoptosis Protein

Identifiers

PMID30670698
PMCPMC6342974
OpenAlexW2913806057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.