Evidence map›Paper›PMID 30670636›Full record

ArticleScience signaling2019

Transcriptional repressor REST drives lineage stage-specific chromatin compaction at

Tara H W Dobson, Rong-Hua Tao, Jyothishmathi Swaminathan, Shinji Maegawa, Shavali Shaik, Javiera Bravo-Alegria, Ajay Sharma, Bridget Kennis, Yanwen Yang, Keri Callegari and 13 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science signaling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 31 citations in OpenAlex.

  1. International journal of molecular sciences · 2026
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  14. Medulloblastoma: novel insights into emerging therapeutic targets.Expert opinion on therapeutic targets · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 6 institutions in 2 countries.

Tara H W DobsonDepartment of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0003-1197-775X
Rong-Hua TaoDepartment of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-3391-8155
Jyothishmathi SwaminathanDepartment of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
Shinji MaegawaDepartment of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
Shavali ShaikDepartment of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
Javiera Bravo-AlegriaDepartment of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-2365-8409
Ajay SharmaDepartment of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
Bridget KennisDepartment of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
Yanwen YangDepartment of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
Keri CallegariDepartment of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0003-1433-6659
Amanda R HaltomDepartment of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
Pete TaylorDepartment of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0003-2455-3411
Mari KogisoTexas Children's Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
Lin QiTexas Children's Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
Soumen KhatuaDepartment of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
Stewart GoldmanDepartment of Pediatrics, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0003-0134-1352
Rishi R LullaDepartment of Pediatrics, Northwestern University, Chicago, IL 60611, USA.
Jason FangusaroDepartment of Pediatrics, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0003-3099-5259
Tobey J MacDonaldDepartment of Pediatrics, Emory University, Atlanta, GA 30322, USA.
Xiao-Nan LiTexas Children's Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-6719-3789
Cynthia HawkinsDepartment of Pathology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
Veena RajaramDepartment of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-2128-2006
Vidya GopalakrishnanDepartment of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA. vgopalak@mdanderson.org.ORCID 0000-0002-4448-4698
The University of Texas MD Anderson Cancer Center · USNorthwestern University · USBaylor College of Medicine · USEmory University · USHospital for Sick Children · CASouthwestern Medical Center · US

Funding

Study of a Novel Deubiquitylase in MedulloblastomaR01NS079715 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GOPALAKRISHNAN, VIDYA · 2012 to 2015
$1.4M
(PQD-5) Patient derived orthotopic xenograft models for drug response predictionR01CA185402 · NCI · BAYLOR COLLEGE OF MEDICINE · PI LI, XIAONAN · 2014 to 2017
$1.3M
Development of Novel Mouse Models to Study REST Function in MedulloblastomaR03NS077021 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GOPALAKRISHNAN, VIDYA · 2011 to 2012
$158k
NCI NIH HHS R01 CA185402NINDS NIH HHS R01 NS079715NINDS NIH HHS R03 NS077021
6 · The paper itself

Abstract

In medulloblastomas (MBs), the expression and activity of RE1-silencing transcription factor (REST) is increased in tumors driven by the sonic hedgehog (SHH) pathway, specifically the SHH-α (children 3 to 16 years) and SHH-β (infants) subgroups. Neuronal maturation is greater in SHH-β than SHH-α tumors, but both correlate with poor overall patient survival. We studied the contribution of REST to MB using a transgenic mouse model (

Indexed as

AdultAnimalsCell Line, TumorCerebellar NeoplasmsChildChromatinDisease Models, AnimalFemaleGene Expression Regulation, NeoplasticHedgehog ProteinsHumansInfantMaleMedulloblastomaMice, Inbred C57BLMice, Inbred NODChromatinHedgehog ProteinsPatched-1 ReceptorProto-Oncogene Proteins c-aktRE1-Silencing Transcription FactorRepressor Proteins

Identifiers

PMID30670636
PMCPMC8939892
OpenAlexW2911476334

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.