Evidence map›Paper›PMID 30670613›Full record

ReviewmBio2019

Challenges in Quantifying Cytosine Methylation in the HIV Provirus.

Sarah A LaMere, Antoine Chaillon, Christina Huynh, Davey M Smith, Sara Gianella

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Targeting Epigenetics to Cure HIV-1: Lessons From (and for) Cancer Treatment.Frontiers in cellular and infection microbiology · 2021
    Review
  6. Deciphering DNA Methylation in HIV Infection.Frontiers in immunology · 2021
    Review
  7. Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sarah A LaMereDepartment of Medicine, University of California San Diego, La Jolla, California, USA salamere@ucsd.edu.
Antoine ChaillonDepartment of Medicine, University of California San Diego, La Jolla, California, USA.ORCID 0000-0001-9490-3857
Christina HuynhDepartment of Medicine, University of California San Diego, La Jolla, California, USA.
Davey M SmithDepartment of Medicine, University of California San Diego, La Jolla, California, USA.
Sara GianellaDepartment of Medicine, University of California San Diego, La Jolla, California, USA.
University of California San Diego · US

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Maile Ann Young Karris · 1994 to 2026
$78.4M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAVID J MOORE · 2001 to 2026
$50.4M
Primary Infection Resource Consortium (PIRC)R24AI106039 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LITTLE, SUSAN JANET · 2013 to 2021
$23.1M
Revealing Reservoirs during Rebound (R3)P01AI131385 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WEIBEL, NADIR · 2017 to 2021
$8.7M
Perturbing the HIV Reservoir with Immune StimulationR01AI118422 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SMITH, DAVID MITCHELL · 2016 to 2020
$3.8M
UCSD Research Training Program for VeterinariansT32OD017863 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ERNST, PETER B., SIGURDSON, CHRISTINA · 2014 to 2023
$2.0M
Comparative Retroviral EpigenomicsK01OD026565 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LAMERE, SARAH ADRIANNE · 2018 to 2023
$797k
Effect of Declining Sex Hormones on HIV persistence in HIV Infected Women on ARTR21HD094646 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GIANELLA WEIBEL, SARA · 2017 to 2018
$441k
The Prostate as a Reservoir for Residual ReplicationR21AI131971 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHAILLON, ANTOINE · 2018 to 2019
$432k
Effect of Sex Hormones on HIV persistenceR21AI134295 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GIANELLA WEIBEL, SARA · 2017 to 2018
$426k
NIAID NIH HHS P01 AI131385NIAID NIH HHS P30 AI036214NIAID NIH HHS R01 AI118422NIAID NIH HHS R21 AI131971NIAID NIH HHS R21 AI134295NIAID NIH HHS R24 AI106039NICHD NIH HHS R21 HD094646NIH HHS K01 OD026565NIH HHS T32 OD017863NIMH NIH HHS P30 MH062512
6 · The paper itself

Abstract

DNA methylation is an epigenetic mechanism most commonly associated with transcriptional repression. While it is clear that DNA methylation can silence HIV proviral expression in

Indexed as

DNA MethylationEpigenesis, GeneticVirus LatencyCytosineDNA, ViralGene Expression Regulation, ViralHIVProvirusesCytosineDNA, Viralcytosine methylationepigenetic silencingHIV latencynon-CpG methylation

Identifiers

PMID30670613
PMCPMC6343035
OpenAlexW2914155940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.