Evidence map›Paper›PMID 30670569›Full record

ArticleMolecular and cellular biology2019

Generation and Molecular Characterization of Human Ring Sideroblasts: a Key Role of Ferrous Iron in Terminal Erythroid Differentiation and Ring Sideroblast Formation.

Kei Saito, Tohru Fujiwara, Shunsuke Hatta, Masanobu Morita, Koya Ono, Chie Suzuki, Noriko Fukuhara, Yasushi Onishi, Yukio Nakamura, Shin Kawamata and 3 more

Open access · greenAbstract read
In one paragraph

Article in Molecular and cellular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Kei SaitoDepartment of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Tohru FujiwaraDepartment of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Shunsuke HattaDepartment of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Masanobu MoritaDepartment of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Koya OnoDepartment of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Chie SuzukiDepartment of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Noriko FukuharaDepartment of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Yasushi OnishiDepartment of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Yukio NakamuraCell Engineering Division, RIKEN BioResource Center, Tsukuba, Ibaraki, Japan.
Shin KawamataDivision of Cell Therapy, Foundation of Biomedical Research and Innovation, Kobe, Japan.
Ritsuko ShimizuDepartment of Molecular Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Masayuki YamamotoDepartment of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hideo HarigaeDepartment of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan harigae@med.tohoku.ac.jp.
Tohoku University · JPFoundation for Biomedical Research and Innovation · JPRIKEN BioResource Research Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ring sideroblasts are a hallmark of sideroblastic anemia, although little is known about their characteristics. Here, we first generated mutant mice by disrupting the GATA-1 binding motif at the intron 1 enhancer of the

Indexed as

5-Aminolevulinate SynthetaseAnemia, SideroblasticAnimalsBone MarrowCell DifferentiationErythroblastsErythroid Precursor CellsFemaleGATA1 Transcription FactorGenetic Diseases, X-LinkedHumansInduced Pluripotent Stem CellsIronMaleMembrane Transport ProteinsMice5-Aminolevulinate SynthetaseALAS2 protein, humanALAS2 protein, mouseGATA1 Transcription FactorIronMembrane Transport Proteins5-aminolevulinic acid synthase 2erythroid cellshemeironX-linked sideroblastic anemia

Identifiers

PMID30670569
PMCPMC6425143
OpenAlexW2912686894

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.