Evidence map›Paper›PMID 30670557›Full record

ArticleInfection and immunity2019

Shiga Toxin Type 1a (Stx1a) Reduces the Toxicity of the More Potent Stx2a

Courtney D Petro, Eszter Trojnar, James Sinclair, Zhi-Mei Liu, Mark Smith, Alison D O'Brien, Angela Melton-Celsa

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Shiga Toxin-ProducingMicroorganisms · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. The diverse landscape of AB5-type toxins.Engineering microbiology · 2023
    Review
  7. Article
  8. The "Big Six": Hidden Emerging Foodborne Bacterial Pathogens.Tropical medicine and infectious disease · 2022
    Review
  9. Article
  10. Article
  11. Diversity of Non-O157 Shiga Toxin-ProducingAnimals : an open access journal from MDPI · 2021
    Article
  12. Shiga Toxin-ProducingMicroorganisms · 2021
    Article
  13. Review
  14. Article
  15. Abundance and Expression of Shiga Toxin Genes inFrontiers in cellular and infection microbiology · 2021
    Article
  16. Review
  17. Observational
  18. Article
  19. The Virulence ofFrontiers in cellular and infection microbiology · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Courtney D PetroDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Eszter TrojnarDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
James SinclairDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Zhi-Mei LiuDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Mark SmithDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Alison D O'BrienDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Angela Melton-CelsaDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA angela.melton-celsa@usuhs.edu.
Uniformed Services University of the Health Sciences · US

Funding

SHIGA-LIKE TOXIN OF ESCHERICHIA COLIR01AI020148 · NIAID · U.S. UNIFORMED SERVICES UNIV OF HLTH SCI · PI MELTON-CELSA, ANGELA · 1987 to 2017
$3.3M
NIAID NIH HHS R01 AI020148
6 · The paper itself

Abstract

Shiga toxin (Stx)-producing

Indexed as

AnimalsChlorocebus aethiopsEscherichia coli InfectionsHumansMaleMiceMice, Inbred BALB CShiga-Toxigenic Escherichia coliShiga Toxin 1Shiga Toxin 2Vero CellsVirulenceShiga Toxin 1Shiga Toxin 2Escherichia colihemolytic-uremic syndromeO26:H11Shiga toxinStx1Stx2

Identifiers

PMID30670557
PMCPMC6434123
OpenAlexW2924796495

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.