ReviewCold Spring Harbor perspectives in medicine2019
Recording and Decoding of Vagal Neural Signals Related to Changes in Physiological Parameters and Biomarkers of Disease.
Review in Cold Spring Harbor perspectives in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Autonomic and neural responses to varying transcutaneous cervical electrical stimulation parameters.Bioelectronic medicine · 2026Article
- Recent advances in facilitating the translation of bioelectronic medicine therapies.Current opinion in biomedical engineering · 2025Article
- Next generation bioelectronic medicine: making the case for non-invasive closed-loop autonomic neuromodulation.Bioelectronic medicine · 2025Review
- Non-invasive ventral cervical magnetoneurography as a proxy of in vivo lipopolysaccharide-induced inflammation.Communications biology · 2024Article
- Computational models of compound nerve action potentials: Efficient filter-based methods to quantify effects of tissue conductivities, conduction distance, and nerve fiber parameters.PLoS computational biology · 2024Article
- Signal processing in the vagus nerve: Hypotheses based on new genetic and anatomical evidence.Biological psychology · 2023Review
- Importance of timing optimization for closed-loop applications of vagus nerve stimulation.Bioelectronic medicine · 2023Review
- Calcium imaging and analysis of the jugular-nodose ganglia enables identification of distinct vagal sensory neuron subsets.Journal of neural engineering · 2023Article
- Closed-Loop Vagus Nerve Stimulation for the Treatment of Cardiovascular Diseases: State of the Art and Future Directions.Frontiers in cardiovascular medicine · 2022Review
- A method to quantify autonomic nervous system function in healthy, able-bodied individuals.Bioelectronic medicine · 2021Article
- Direct measurement of vagal tone in rats does not show correlation to HRV.Scientific reports · 2021Article
- The Vagal Autonomic Pathway of COVID-19 at the Crossroad of Alzheimer's Disease and Aging: A Review of Knowledge.Journal of Alzheimer's disease reports · 2020Review
- Intraneural ultramicroelectrode arrays for function-specific interfacing to the vagus nerve.Biosensors & bioelectronics · 2020Article
- tACS entrains neural activity while somatosensory input is blocked.PLoS biology · 2020Article
- An impedance matching algorithm for common-mode interference removal in vagus nerve recordings.Journal of neuroscience methods · 2020Article
- Closed-loop bioelectronic medicine for diabetes management.Bioelectronic medicine · 2020Review
- Identification of hypoglycemia-specific neural signals by decoding murine vagus nerve activity.Bioelectronic medicine · 2019Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our bodies have built-in neural reflexes that continuously monitor organ function and maintain physiological homeostasis. Whereas the field of bioelectronic medicine has mainly focused on the stimulation of neural circuits to treat various conditions, recent studies have started to investigate the possibility of leveraging the sensory arm of these reflexes to diagnose disease states. To accomplish this, neural signals emanating from the body's built-in biosensors and propagating through peripheral nerves must be recorded and decoded to identify the presence or levels of relevant biomarkers of disease. The process of acquiring these signals poses several technical challenges related to the neural interfaces, surgical techniques, and data-processing framework needed to record and analyze them. However, these challenges can be addressed with a rigorous experimental approach and new advances in implantable electrodes, signal processing, and machine learning methods. Outlined in this review are studies decoding vagus nerve activity as it related to inflammatory, metabolic, and cardiopulmonary biomarkers. Successfully decoding peripheral nerve activity related to disease states will not only enable the development of real-time diagnostic devices, but also help advancing truly closed-loop neuromodulation technologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.