ArticleThe Journal of experimental medicine2019
Self-reactive CD4
Open access · bronzeAbstract read
In one paragraph
Article in The Journal of experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Immunomodulating Therapies in Acute Myocarditis and Recurrent/Acute Pericarditis.Frontiers in medicine · 2022Pooled it
- Context-Dependent Regulation of Microglial Metabolic and Immune States via IL-3/CD123 Signaling: Implications for Glial Crosstalk and Cognitive Impairment.Molecular neurobiology · 2026Review
- Fibrosis-memory is mediated by IL-3-producing T cells and drives progression of fibrosis.The Journal of clinical investigation · 2026Article
- High-salt diet aggravates skin inflammation of psoriasis-like mouse model with CCL20‒CCR6 axis further activation.JID innovations : skin science from molecules to population health · 2026Article
- Prognostic nutritional index in risk of mortality following fulminant myocarditis.Scientific reports · 2025Article
- Persistent somatostatin PET signs of inflammatory cells 4 to 5 months after acute myocarditis are linked to a poorer recovery of cardiac function.European journal of nuclear medicine and molecular imaging · 2025Article
- Review
- Autoimmunity in Cardiomyopathy-Induced Heart Failure and Cardiac Autoantibody Removal by Immunoadsorption.Journal of clinical medicine · 2025Review
- The Immune System, An Arrow into the Heart. Principles of Cardioimmunology, An Emerging Branch in Medicine.Current vascular pharmacology · 2025Review
- The distinct functions of MIF in inflammatory cardiomyopathy.Frontiers in immunology · 2025Review
- Review
- Current understanding and management of cardiovascular involvement in rheumatic immune-mediated inflammatory diseases.Nature reviews. Rheumatology · 2024Review
- E3 ubiquitin ligase RNF128 negatively regulates the IL-3/STAT5 signaling pathway by facilitating K27-linked polyubiquitination of IL-3Rα.Cell communication and signaling : CCS · 2024Article
- Review
- IL-3: key orchestrator of inflammation.Frontiers in immunology · 2024Review
- High placental expression of FLT1, LEP, PHYHIP and IL3RA - In persons of African ancestry with severe preeclampsia.Placenta · 2023Article
- Emerging Roles for Dendritic Cells in Heart Failure.Biomolecules · 2023Review
- ANGPTL2 promotes immune checkpoint inhibitor-related murine autoimmune myocarditis.Communications biology · 2023Article
- Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis.Immunity · 2023Article
- Identification of key biomarkers associated with immune cells infiltration for myocardial injury in dermatomyositis by integrated bioinformatics analysis.Arthritis research & therapy · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 4 institutions in 2 countries.
Atsushi AnzaiCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
John E MindurCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.ORCID 0000-0002-2212-3904
Lennard HalleCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Soichi SanoHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA.
Jennifer L ChoiCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.ORCID 0000-0003-0015-8601
Shun HeCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Cameron S McAlpineCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Christopher T ChanCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Florian KahlesCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Colin ValetCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Ashley M FennCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Manfred NairzCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Sara RattikCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Yoshiko IwamotoCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
DeLisa FairweatherDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL.ORCID 0000-0003-3093-1810
Kenneth WalshHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA.
Peter LibbyCardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA.ORCID 0000-0002-1502-502X
Matthias NahrendorfCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.ORCID 0000-0002-4021-1887
Filip K SwirskiCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA fswirski@mgh.harvard.edu.ORCID 0000-0002-3163-9152
Harvard University · USUniversity of Virginia · USBrigham and Women's Hospital · USJacksonville College · US
Funding
Translational imaging and nanomedicine in inflammatory atherosclerosisP01HL131478 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Zahi A. Fayad · 2017 to 2026
$24.3MMacrophages in homeostasis and cardiovascular diseaseR35HL135752 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SWIRSKI, FILIP K · 2017 to 2023
$5.4MLifestyle effects on hematopoiesis and atherosclerosisR01HL128264 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAHRENDORF, MATTHIAS, SWIRSKI, FILIP K · 2015 to 2018
$3.3MInflammatory Wnt signaling in ischemic myocardiumR01HL131006 · NHLBI · UNIVERSITY OF VIRGINIA · PI WALSH, KENNETH · 2016 to 2019
$2.1MSex Differences in Complement during Myocarditis/DCMR01HL111938 · NHLBI · MAYO CLINIC JACKSONVILLE · PI FAIRWEATHER, DELISA · 2012 to 2015
$1.6MEndocrine disruptors effect on inflammatory heart diseaseR21ES024414 · NIEHS · MAYO CLINIC JACKSONVILLE · PI FAIRWEATHER, DELISA · 2014 to 2015
$440kCIHRNHLBI NIH HHS P01 HL131478NHLBI NIH HHS R01 HL111938NHLBI NIH HHS R01 HL128264NHLBI NIH HHS R01 HL131006NHLBI NIH HHS R35 HL135752NIEHS NIH HHS R21 ES024414
Abstract
Acquisition of self-reactive effector CD4
Indexed as
AnimalsAutoimmune DiseasesCD4-Positive T-LymphocytesCell ProliferationChemotaxisInterleukin-3MacrophagesMiceMice, Inbred BALB CMice, KnockoutMonocytesMyocarditisInterleukin-3
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.