Evidence map›Paper›PMID 30670422›Full record

ArticleAntimicrobial agents and chemotherapy2019

Early Detection of Emergent Extensively Drug-Resistant Tuberculosis by Flow Cytometry-Based Phenotyping and Whole-Genome Sequencing.

Max R O'Donnell, Michelle H Larsen, Tyler S Brown, Paras Jain, Vanisha Munsamy, Allison Wolf, Lorenzo Uccellini, Farina Karim, Tulio de Oliveira, Barun Mathema and 2 more

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Max R O'DonnellDivision of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York, New York, USA mo2130@columbia.edu.
Michelle H LarsenHoward Hughes Medical Institute, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Tyler S BrownInfectious Diseases Division, Massachusetts General Hospital, Boston, Massachusetts, USA.
Paras JainHoward Hughes Medical Institute, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Vanisha MunsamyAfrica Health Research Institute (AHRI), Durban, South Africa.
Allison WolfDivision of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York, New York, USA.
Lorenzo UccelliniDivision of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York, New York, USA.
Farina KarimAfrica Health Research Institute (AHRI), Durban, South Africa.
Tulio de OliveiraKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Barun MathemaDepartment of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, New York, USA.
William R JacobsHoward Hughes Medical Institute, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Alexander PymAfrica Health Research Institute (AHRI), Durban, South Africa.
Columbia University Irving Medical Center · USAfrica Health Research Institute · ZAHoward Hughes Medical Institute · USAlbert Einstein College of Medicine · USMassachusetts General Hospital · USUniversity of KwaZulu-Natal · ZA

Funding

INFECTIOUS DISEASE AND BASIC MICROBIOLOGICAL MECHANISMST32AI007061 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Marcia B Goldberg · 1985 to 2026
$12.1M
Novel Reporter Phages to Detect Complex TB Drug Resistance and PersistenceR01AI114900 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Michelle H Larsen, Max O'Donnell · 2015 to 2026
$7.2M
Biomarker for XDR-TB Treatment Response and Drug Resistance in HIV Endemic AreaK23AI098479 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI O'DONNELL, MAX · 2012 to 2016
$669k
NIAID NIH HHS K23 AI098479NIAID NIH HHS R01 AI114900NIAID NIH HHS T32 AI007061
6 · The paper itself

Abstract

A critical gap in tuberculosis (TB) treatment is detection of emergent drug resistance. We hypothesized that advanced phenotyping with whole-genome sequencing (WGS) will detect low-frequency

Indexed as

Antitubercular AgentsBacteriophagesDrug Resistance, BacterialExtensively Drug-Resistant TuberculosisFlow CytometryGreen Fluorescent ProteinsHumansMicrobial Sensitivity TestsMycobacterium tuberculosisPolymorphism, Single NucleotideRifampinSputumTuberculosis, PulmonaryWhole Genome SequencingAntitubercular AgentsGreen Fluorescent ProteinsRifampinextensively drug-resistant tuberculosisheteroresistancephageSouth Africatuberculosiswhole-genome sequencing

Identifiers

PMID30670422
PMCPMC6437479
OpenAlexW2910974880

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.