Evidence map›Paper›PMID 30670420›Full record

ArticleAntimicrobial agents and chemotherapy2019

CMCdG, a Novel Nucleoside Analog with Favorable Safety Features, Exerts Potent Activity against Wild-Type and Entecavir-Resistant Hepatitis B Virus.

Nobuyo Higashi-Kuwata, Sanae Hayashi, Debananda Das, Satoru Kohgo, Shuko Murakami, Shin-Ichiro Hattori, Shuhei Imoto, David J Venzon, Kamalendra Singh, Stefan G Sarafianos and 2 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  3. Review
  4. Review
  5. Article
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nobuyo Higashi-KuwataDepartment of Refractory Viral Infections, National Center for Global Health & Medicine Research Institute, Tokyo, Japan.
Sanae HayashiDepartment of Virology & Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Debananda DasExperimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Satoru KohgoDepartment of Refractory Viral Infections, National Center for Global Health & Medicine Research Institute, Tokyo, Japan.
Shuko MurakamiDepartment of Virology & Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Shin-Ichiro HattoriDepartment of Refractory Viral Infections, National Center for Global Health & Medicine Research Institute, Tokyo, Japan.
Shuhei ImotoFaculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.
David J VenzonBiostatistics and Data Management Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-8990-158X
Kamalendra SinghLaboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Stefan G SarafianosLaboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Yasuhito TanakaDepartment of Virology & Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Hiroaki MitsuyaDepartment of Refractory Viral Infections, National Center for Global Health & Medicine Research Institute, Tokyo, Japan hiroaki.mitsuya2@nih.gov.ORCID 0000-0001-9274-3853

Funding

Development of Novel Agents Active against Hepatitis B VirusZIABC011486 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MITSUYA, HIROAKI · 2013 to 2025
$3.0M
Taking aim at HBV eradication using novel NRTIs and Capsid effectorsR01AI121315 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI SARAFIANOS, STEFAN G, WANG, ZHENGQIANG · 2016 to 2020
$3.0M
NIAID NIH HHS R01 AI121315
6 · The paper itself

Abstract

We designed, synthesized, and characterized a novel nucleoside analog, (1

Indexed as

AnimalsAntiviral AgentsCell Line, TumorDNA ReplicationDrug DiscoveryDrug Resistance, ViralGuanineHepatitis BHepatitis B virusHep G2 CellsHumansMiceNucleosidesPurinesReverse Transcriptase InhibitorsSerum AlbuminAntiviral AgentsentecavirGuanineNucleosidesPurinesReverse Transcriptase InhibitorsSerum Albuminanti-HBV drugsdrug-resistant HBV variantshuman liver-chimeric micemolecular modelingnucleoside/nucleotide reverse transcriptase inhibitors

Identifiers

PMID30670420
PMCPMC6437475

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.