Evidence map›Paper›PMID 30670389›Full record

ArticleAnnals of family medicine2019

Impact of Repeated Influenza Immunization on Respiratory Illness in Children With Preexisting Medical Conditions.

Marieke L A de Hoog, Roderick P Venekamp, Roger A M J Damoiseaux, Anne G M Schilder, Elisabeth A M Sanders, Henriette A Smit, Patricia C J L Bruijning-Verhagen

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of family medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Marieke L A de HoogJulius Center for Health Sciences and Primary Care, University Medical Center, Utrecht University, The Netherlands m.l.a.dehoog@umcutrecht.nl.
Roderick P VenekampJulius Center for Health Sciences and Primary Care, University Medical Center, Utrecht University, The Netherlands.
Roger A M J DamoiseauxJulius Center for Health Sciences and Primary Care, University Medical Center, Utrecht University, The Netherlands.
Anne G M SchilderJulius Center for Health Sciences and Primary Care, University Medical Center, Utrecht University, The Netherlands.
Elisabeth A M SandersWilhelmina Children's Hospital, University Medical Center, Utrecht University, The Netherlands.
Henriette A SmitJulius Center for Health Sciences and Primary Care, University Medical Center, Utrecht University, The Netherlands.
Patricia C J L Bruijning-VerhagenJulius Center for Health Sciences and Primary Care, University Medical Center, Utrecht University, The Netherlands.
Utrecht University · NLUniversity Medical Center Utrecht · NL

Funding

Department of Health NIHR-RP-011-045
6 · The paper itself

Abstract

purposeAnnual influenza immunization in medical risk groups is recommended in many countries. Recent evidence suggests that repeated inactivated influenza vaccine (IIV) immunization throughout childhood may impair long-term immunity against influenza. We assessed whether prior immunization altered the effect of IIV in children with preexisting medical conditions on primary care-diagnosed respiratory illness (RI) episodes during the influenza season.

methodsElectronic records of IIV-immunized children who met the criteria for annual IIV immunization according to Dutch guidelines were extracted from a primary care database from 2004 to 2015. For each year, we collected information on IIV immunization status, primary care-attended RI episodes (including influenza-like illness, acute RI, and asthma exacerbation), and potential confounders. Generalized estimating equations were used to model the association between prior IIV and occurrence of at least one RI episode during the influenza season, with "current year immunized but without IIV history" as reference group.

resultsA total of 4,183 children (follow-up duration: 11,493 child-years) were IIV immunized at least once. Adjusted estimates showed lower odds for RI in current year-immunized children with prior IIV compared with those without (odds ratio [OR] = 0.61; 95% CI, 0.47-0.78 for "current year immunized and one IIV in previous 2 years"; OR = 0.85; 95% CI, 0.68-1.07 for "current year immunized and ≥2 IIVs in previous 3 years, including prior year").

conclusionRepeated IIV immunization in children with preexisting medical conditions has no negative impact on, and may even increase, long-term protection against RI episodes diagnosed during the influenza season in primary care.

Indexed as

AdolescentChildChild, PreschoolFemaleHumansInfantInfluenza, HumanInfluenza VaccinesMaleNetherlandsPreexisting Condition CoverageRespiratory Tract DiseasesInfluenza Vaccineschildrenimmunizationinfluenzapediatricspreexisting medical conditionrespiratory illness

Identifiers

PMID30670389
PMCPMC6342594
OpenAlexW2913912512

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.