Evidence map›Paper›PMID 30670009›Full record

Trial reportBMC cancer2019

Multimodal prehabilitation in colorectal cancer patients to improve functional capacity and reduce postoperative complications: the first international randomized controlled trial for multimodal prehabilitation.

Stefanus van Rooijen, Francesco Carli, Susanne Dalton, Gwendolyn Thomas, Rasmus Bojesen, Morgan Le Guen, Nicolas Barizien, Rashami Awasthi, Enrico Minnella, Sandra Beijer and 9 more

3 registry-linked trialsAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 167 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
167citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04153721 nacompletednot on this mapstarted 2020, after this paper: background citation

Evaluation of a Digital Perioperative Support Solution for Colorectal Surgery: Compliance and Impact on Patients

TypeinterventionalSponsorIHU StrasbourgRan2020 to 2023Enrolled22ConditionsColorectal CancerArmsName Digital Solution
NCT06607081 nanot yet recruitingnot on this mapstarted 2024, after this paper: background citation

The Preoperative Risk Evaluation and Perioperative ERAS Intervention in the Chinese Elderly Patients Underwent Spinal Fusion Surgery

TypeinterventionalSponsorXijing HospitalRan2024 to 2027Enrolled5,000ConditionsDegenerative Spinal Disease, Elderly Patients, Spinal Fusion AcquiredArmsMultidisciplinary Preoperative Risk Evaluation and the Corresponded Pre ERAS intervention
NCT07529301 recruitingnot on this mapstarted 2026, after this paper: background citation

The Effect of Functional Status and Respiratory Parameters on Early Postoperative Clinical Outcomes in Patients With Colorectal Cancer

Typeobservational_patient_registrySponsorMüşerref Ebru YALÇINRan2026 to 2027Enrolled42ConditionsColorectal Cancer, Functional Status, Respiratory Parameters, Clinical OutcomesArmsPreoperative Assessments, Postoperative Assessments (Daily from Postoperative Day 1 Until Discharge)
3 · Its place in the literature

Who cites it

167 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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  10. Fit4Surgery for cancer patients during covid-19 lockdown - A systematic review and meta-analysis.European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2022
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  15. Trial
  16. Effectiveness of Orem's self-care model nursing combined with nutritional intervention in postoperative patients with colorectal cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  17. The effects of psychological intervention on negative emotions, pain, and sleep in patients with advanced colon cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
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107 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Stefanus van RooijenDepartment of Surgical Oncology, Máxima Medical Center, Veldhoven, the Netherlands.ORCID http://orcid.org/0000-0002-9275-5552
Francesco CarliDepartment of Anesthesiology, the Montréal General Hospital, McGill University, Montréal, Canada.
Susanne DaltonDanish Cancer Society Research Center, Copenhagen, Denmark.
Gwendolyn ThomasDepartment of Surgical Oncology, Máxima Medical Center, Veldhoven, the Netherlands.
Rasmus BojesenDepartment of Surgery, Center for Surgical Science, Zealand University Hospital, Køge, Denmark.
Morgan Le GuenDepartment of Anesthesiology, Foch Hôpital, Paris, France.
Nicolas BarizienDepartment of Sports Medicine, Foch Hôpital, Paris, France.
Rashami AwasthiDepartment of Anesthesiology, the Montréal General Hospital, McGill University, Montréal, Canada.
Enrico MinnellaDepartment of Anesthesiology, the Montréal General Hospital, McGill University, Montréal, Canada.
Sandra BeijerNetherlands Comprehensive Cancer Organisation, Utrecht, the Netherlands.
Graciela Martínez-PalliDepartment of Anesthesiology, Hospital Clinic de Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain.
Rianne van LieshoutDepartment of Nutrition, Máxima Medical Center, Veldhoven, the Netherlands.
Ismayil GögenurDepartment of Surgery, Center for Surgical Science, Zealand University Hospital, Køge, Denmark.
Carlo FeoDepartment of Surgery, S. Anna University Hospital, Ferrara, Italy.
Christoffer JohansenDanish Cancer Society Research Center, Copenhagen, Denmark.
Celena Scheede-BergdahlDepartment of Surgery, Center for Surgical Science, Zealand University Hospital, Køge, Denmark.
Rudi RoumenDepartment of Surgical Oncology, Máxima Medical Center, Veldhoven, the Netherlands.
Goof SchepDepartment of Sports Medicine, Máxima Medical Center, Veldhoven, the Netherlands.
Gerrit SlooterDepartment of Surgical Oncology, Máxima Medical Center, Veldhoven, the Netherlands. g.slooter@mmc.nl.

Funding

KWF Kankerbestrijding 10690
6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) is the second most prevalent type of cancer in the world. Surgery is the only curative option. However, postoperative complications occur in up to 50% of patients and are associated with higher morbidity and mortality rates, lower health related quality of life (HRQoL) and increased expenditure in health care. The number and severity of complications are closely related to preoperative functional capacity, nutritional state, psychological state, and smoking behavior. Traditional approaches have targeted the postoperative period for rehabilitation and lifestyle changes. However, recent evidence shows that the preoperative period might be the optimal moment for intervention. This study will determine the impact of multimodal prehabilitation on patients' functional capacity and postoperative complications. METHODS/

designThis international multicenter, prospective, randomized controlled trial will include 714 patients undergoing colorectal surgery for cancer. Patients will be allocated to the intervention group, which will receive 4 weeks of prehabilitation (group 1, prehab), or the control group, which will receive no prehabilitation (group 2, no prehab). Both groups will receive perioperative care in accordance with the enhanced recovery after surgery (ERAS) guidelines. The primary outcomes for measurement will be functional capacity (as assessed using the six-minute walk test (6MWT)) and postoperative status determined with the Comprehensive Complication Index (CCI). Secondary outcomes will include HRQoL, length of hospital stay (LOS) and a cost-effectiveness analysis. DISCUSSION: Multimodal prehabilitation is expected to enhance patients' functional capacity and to reduce postoperative complications. It may therefore result in increased survival and improved HRQoL. This is the first international multicenter study investigating multimodal prehabilitation for patients undergoing colorectal surgery for cancer.

trial registrationTrial Registry: NTR5947 - date of registration: 1 August 2016.

Indexed as

AdultAgedAged, 80 and overColonic NeoplasmsColorectal NeoplasmsCombined Modality TherapyCost-Benefit AnalysisDigestive System Surgical ProceduresHumansMiddle AgedPostoperative ComplicationsPostoperative PeriodPreoperative CareProspective StudiesRecovery of FunctionTreatment OutcomeColorectal cancerColorectal surgeryComprehensive complication indexEnhanced recovery after surgeryFunctional capacityPostoperative complicationsPrehabilitation

Identifiers

PMID30670009
PMCPMC6341758

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.