Evidence map›Paper›PMID 30669968›Full record

ArticleBMC anesthesiology2019

Population pharmacokinetic-pharmacodynamic model of propofol in adolescents undergoing scoliosis surgery with intraoperative wake-up test: a study using Bispectral index and composite auditory evoked potentials as pharmacodynamic endpoints.

Heleen J Blussé van Oud-Alblas, Margreke J E Brill, Mariska Y M Peeters, Dick Tibboel, Meindert Danhof, Catherijne A J Knibbe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC anesthesiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Modelling the PSI response in general anesthesia.Journal of clinical monitoring and computing · 2021
    Article
  7. The role of population PK-PD modelling in paediatric clinical research.European journal of clinical pharmacology · 2011
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Heleen J Blussé van Oud-AlblasDepartment of Anesthesiology, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-7167-5545
Margreke J E BrillDivision of Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.
Mariska Y M PeetersDepartment of Clinical Pharmacy, St. Antonius Hospital, P.O. Box 2500, 3430 EM, Nieuwegein, The Netherlands.
Dick TibboelDepartment of Pediatric Intensive Care, Erasmus Medical Center - Sophia Children's Hospital, Rotterdam, The Netherlands.
Meindert DanhofDivision of Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.
Catherijne A J KnibbeDivision of Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands. c.knibbe@antoniusziekenhuis.nl.
Leiden University · NLErasmus MC · NLErasmus MC - Sophia Children’s Hospital · NLSt. Antonius Ziekenhuis · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn adolescents limited data are available on the pharmacokinetics (PK) and pharmacodynamics (PD) of propofol. In this study we derived a PK-PD model for propofol in adolescents undergoing idiopathic scoliosis surgery with an intraoperative wake-up test with reinduction of anesthesia using both Bispectral Index (BIS) and composite A-line ARX index (cAAI) as endpoints.

methodsFourteen adolescents (9.8-20.1 years) were evaluated during standardized propofol-remifentanil anesthesia for idiopathic scoliosis surgery with an intraoperative wake-up test with reinduction of anesthesia. BIS and cAAI were continuously measured and blood samples collected. A propofol PKPD model was developed using NONMEM.

resultsThe time courses of propofol concentrations, BIS and cAAI values during anesthesia, intra-operative wakeup and reduction of anesthesia were best described by a two-compartment PK model linked to an inhibitory sigmoidal Emax PD model. For the sigmoidal Emax model, the propofol concentration at half maximum effect (EC

conclusionsA population PKPD model for propofol in adolescents was developed that successfully described the time course of propofol concentration, BIS and cAAI in individuals upon undergoing scoliosis surgery with intraoperative wake-up test and reinduction of anesthesia. Large differences were demonstrated between both monitors. This may imply that BIS and cAAI measure fundamentally different endpoints in the brain.

Indexed as

Models, BiologicalAdolescentAnesthetics, IntravenousChildConsciousness MonitorsEvoked Potentials, AuditoryFemaleHumansMaleMonitoring, IntraoperativePropofolRemifentanilScoliosisWakefulnessYoung AdultAnesthetics, IntravenousPropofolRemifentanilAdolescentsAnesthetic depthAuditory evoked potentialsBispectral indexPharmacodynamicsPharmacokineticsPopulation PKPD modelingPropofol

Identifiers

PMID30669968
PMCPMC6343297
OpenAlexW2920333403

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.