ArticleMarine drugs2019
Integrated Genomic and Metabolomic Approach to the Discovery of Potential Anti-Quorum Sensing Natural Products from Microbes Associated with Marine Samples from Singapore.
Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Role ofJournal of microbiology and biotechnology · 2025Review
- Quorum Sensing Inhibition by Sponge-AssociatedAntibiotics (Basel, Switzerland) · 2025Article
- Natural products as antivibrio agents: insight into the chemistry and biological activity.RSC advances · 2022Review
- Mining Indonesian Microbial Biodiversity for Novel Natural Compounds by a Combined Genome Mining and Molecular Networking Approach.Marine drugs · 2021Article
- Assessing the Diversity and Biomedical Potential of Microbes Associated With the Neptune's Cup Sponge,Frontiers in microbiology · 2021Article
- Monitoring and assessment of the therapeutic impact of metabolites extracted from sponge-associated bacteria screened from Gulf of Mannar, southeast coast of India.Environmental monitoring and assessment · 2020Article
- Microviridin 1777: A Toxic Chymotrypsin Inhibitor Discovered by a Metabologenomic Approach.Journal of natural products · 2020Article
- Article
- Draft Genome Sequence ofMicrobiology resource announcements · 2019Article
- Draft Genome Sequence ofMicrobiology resource announcements · 2019Article
- Linking biosynthetic and chemical space to accelerate microbial secondary metabolite discovery.FEMS microbiology letters · 2019Article
- Widespread Existence of Quorum Sensing Inhibitors in Marine Bacteria: Potential Drugs to Combat Pathogens with Novel Strategies.Marine drugs · 2019Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
With 70% of the Earth's surface covered in water, the marine ecosystem offers immense opportunities for drug discovery and development. Due to the decreasing rate of novel natural product discovery from terrestrial sources in recent years, many researchers are beginning to look seaward for breakthroughs in new therapeutic agents. As part of an ongoing marine drug discovery programme in Singapore, an integrated approach of combining metabolomic and genomic techniques were initiated for uncovering novel anti-quorum sensing molecules from bacteria associated with subtidal samples collected in the Singapore Strait. Based on the culture-dependent method, a total of 102 marine bacteria strains were isolated and the identities of selected strains were established based on their 16S rRNA gene sequences. About 5% of the marine bacterial organic extracts showed quorum sensing inhibitory (QSI) activity in a dose-dependent manner based on the
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Registered trials
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