Evidence map›Paper›PMID 30669568›Full record

ArticleCancers2019

Location-Dependent Patient Outcome and Recurrence Patterns in IDH1-Wildtype Glioblastoma.

Christine Jungk, Rolf Warta, Andreas Mock, Sara Friauf, Bettina Hug, David Capper, Amir Abdollahi, Jürgen Debus, Martin Bendszus, Andreas von Deimling and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Christine JungkDivision of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg, INF 400, D-69120 Heidelberg, Germany. christine.jungk@med.uni-heidelberg.de.
Rolf WartaDivision of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg, INF 400, D-69120 Heidelberg, Germany. rolf.warta@med.uni-heidelberg.de.ORCID 0000-0003-2821-4361
Andreas MockDivision of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg, INF 400, D-69120 Heidelberg, Germany. andreas.mock@med.uni-heidelberg.de.
Sara FriaufDivision of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg, INF 400, D-69120 Heidelberg, Germany. sara.friauf@med.uni-heidelberg.de.
Bettina HugDepartment of Neuroradiology, Clinic of Neurology, University Hospital Heidelberg, INF 400, D-69120 Heidelberg, Germany. bettina.hug@muerle.de.
David CapperDepartment of Neuropathology, Institute of Pathology, University of Heidelberg, German Cancer Consortium, CCU Neuropathology, German Cancer Research Center, INF 224, D-69120 Heidelberg, Germany. david.capper@charite.de.
Amir AbdollahiDepartment of Radiation Oncology, Heidelberg University Hospital, Molecular and Translational Radiation Oncology, National Center for Tumor Diseases, German Cancer Research Center, D-69120 Heidelberg, Germany. amir.abdollahi@med.uni-heidelberg.de.
Jürgen DebusDepartment of Radiation Oncology, Heidelberg University Hospital, Molecular and Translational Radiation Oncology, National Center for Tumor Diseases, German Cancer Research Center, D-69120 Heidelberg, Germany. juergen.debus@med.uni-heidelberg.de.
Martin BendszusDepartment of Neuroradiology, Clinic of Neurology, University Hospital Heidelberg, INF 400, D-69120 Heidelberg, Germany. martin.bendszus@med.uni-heidelberg.de.
Andreas von DeimlingDepartment of Neuropathology, Institute of Pathology, University of Heidelberg, German Cancer Consortium, CCU Neuropathology, German Cancer Research Center, INF 224, D-69120 Heidelberg, Germany. andreas.vondeimling@med.uni-heidelberg.de.
Andreas UnterbergDivision of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg, INF 400, D-69120 Heidelberg, Germany. andreas.unterberg@med.uni-heidelberg.de.
Christel Herold-MendeDivision of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg, INF 400, D-69120 Heidelberg, Germany. h.mende@med.uni-heidelberg.de.
Heidelberg University · DEGerman Cancer Research Center · DE

Funding

Anni-Hofmann-Foundation N/A
6 · The paper itself

Abstract

Recent studies suggest that glioblastomas (GBMs) contacting the subventricular zone (SVZ) as the main adult neurogenic niche confer a dismal prognosis but disregard the unique molecular and prognostic phenotype associated with isocitrate dehydrogenase 1 (IDH1) mutations. We therefore examined location-dependent prognostic factors, growth, and recurrence patterns in a consecutive cohort of 285 IDH1-wildtype GBMs. Based on pre-operative contrast-enhanced MRI, patients were allotted to four location-dependent groups with (SVZ+; groups I, II) and without (SVZ-; groups III, IV) SVZ involvement or with (cortex+; groups I, III) and without (cortex-; groups II, IV) cortical involvement and compared for demographic, treatment, imaging, and survival data at first diagnosis and recurrence. SVZ involvement was associated with lower Karnofsky performance score (

Indexed as

distant recurrenceGlioblastomaisocitrate dehydrogenase 1 (IDH1)-wildtypemultifocal growthsubventricular zonesurvival

Identifiers

PMID30669568
PMCPMC6356480
OpenAlexW2908690972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.