ArticleInternational journal of molecular sciences2019
A Proteome Approach Reveals Differences between Fertile Women and Patients with Repeated Implantation Failure on Endometrial Level⁻Does hCG Render the Endometrium of RIF Patients?
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- Recent advances in characterizing the immune microenvironment and biomarkers of endometrial carcinoma.Frontiers in immunology · 2026Review
- The Role of Ferroptosis in Women's Health and Diseases.MedComm · 2025Review
- Exploration of ferroptosis-related biomarkers with prognostic capability in RIF based on WGCNA.Journal of assisted reproduction and genetics · 2025Article
- Evaluating endometrial response to human chorionic gonadotropin: alterations in epigenetic regulation and extracellular vesicle cargo of endometrial stromal cells.Human reproduction open · 2025Article
- Dead or Alive: Exploratory Analysis of Selected Apoptosis- and Autophagy-Related Proteins in Human Endometrial Stromal Cells of Fertile Females and Their Potential Role During Embryo Implantation.International journal of molecular sciences · 2024Article
- The Contribution of Proteomics in Understanding Endometrial Protein Expression in Women with Recurrent Implantation Failure.Journal of clinical medicine · 2024Review
- When the Embryo Meets the Endometrium: Identifying the Features Required for Successful Embryo Implantation.International journal of molecular sciences · 2024Review
- Closer to the Reality-Proteome Changes Evoked by Endometrial Scratching in Fertile Females.International journal of molecular sciences · 2023Article
- Transcriptional response of endometrial cells to Insulin, cultured using microfluidics.Reproduction & fertility · 2023Article
- Mechanism of human chorionic gonadotropin in endometrial receptivity via the miR-126-3p/PI3K/Akt/eNOS axis.The Kaohsiung journal of medical sciences · 2023Article
- Investigation of hub ferroptosis-related genes and the immune landscape in recurrent pregnancy loss and unexplained infertility using bioinformatics analysis.Annals of translational medicine · 2023Article
- Solute Carrier Family 7 Member 11 (SLC7A11) is a Potential Prognostic Biomarker in Uterine Corpus Endometrial Carcinoma.International journal of general medicine · 2023Article
- Endometrial proteomic profile of patients with repeated implantation failure.Frontiers in endocrinology · 2023Article
- Endometrium Immunomodulation to Prevent Recurrent Implantation Failure in Assisted Reproductive Technology.International journal of molecular sciences · 2022Review
- Human Chorionic Gonadotropin and Early Embryogenesis: Review.International journal of molecular sciences · 2022Review
- Ferroptosis: Opportunities and Challenges in Treating Endometrial Cancer.Frontiers in molecular biosciences · 2022Review
- Three Oxidative Stress-Related Genes That Associate Endometrial Immune Cells Are Considered as Potential Biomarkers for the Prediction of Unexplained Recurrent Implantation Failure.Frontiers in immunology · 2022Article
- Article
- Steroid hormones and human choriogonadotropin influence the distribution of alpha6-integrin and desmoplakin 1 in gland-like endometrial epithelial spheroids.Histochemistry and cell biology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe molecular signature of endometrial receptivity still remains barely understood, especially when focused on the possible benefit of therapeutical interventions and implantation-related pathologies. Therefore, the protein composition of tissue and isolated primary cells (endometrial stromal cells, ESCs) from endometrial scratchings of ART (Assisted Reproductive Techniques) patients with repeated implantation failure (RIF) was compared to volunteers with proven fertility during the time of embryo implantation (LH + 7). Furthermore, an analysis of the endometrial tissue of fertile women infused with human chorionic gonadotropin (hCG) was conducted.
methodsEndometrial samples (
resultsThree proteins (EPPK1, BCLAF1 and PTMA) showed a statistically altered abundance in the endometrial tissue of RIF patients. Furthermore, pathways like metabolism, immune system, ferroptosis and the endoplasmic reticulum were altered in RIF patients. Remarkably, endometrial tissues of RIF patients showed a significantly higher (
conclusionOur study showed for the first time that the endometrial proteome composition of RIF patients differs from fertile controls during the window of implantation. The intrauterine infusion of hCG prior to an embryo transfer might improve the chemokine triggered embryo-endometrial dialogue and intensify the angiogenesis and immune response. From a clinical point of view, the hCG infusion prior to an embryo transfer might increase the pregnancy rate of RIF patients.
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