Evidence map›Paper›PMID 30669468›Full record

ArticleMolecules (Basel, Switzerland)2019

Selective Targeting of the Interconversion between Glucosylceramide and Ceramide by Scaffold Tailoring of Iminosugar Inhibitors.

Cécile Baudoin-Dehoux, Tessa Castellan, Frédéric Rodriguez, Arnaud Rives, Fabien Stauffert, Virginie Garcia, Thierry Levade, Philippe Compain, Yves Génisson

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Glucocerebrosidase as a therapeutic target for Parkinson's disease.Expert opinion on therapeutic targets · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Cécile Baudoin-DehouxLaboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique (SPCMIB), Université Paul Sabatier-Toulouse III/ CNRS (UMR5068), 118 route de Narbonne, F-31062 Toulouse, France. baudoin@chimie.ups-tlse.fr.
Tessa CastellanLaboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique (SPCMIB), Université Paul Sabatier-Toulouse III/ CNRS (UMR5068), 118 route de Narbonne, F-31062 Toulouse, France. castellan@chimie.ups-tlse.fr.
Frédéric RodriguezLaboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique (SPCMIB), Université Paul Sabatier-Toulouse III/ CNRS (UMR5068), 118 route de Narbonne, F-31062 Toulouse, France. build@chimie.ups-tlse.fr.ORCID 0000-0001-5491-8165
Arnaud RivesLaboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique (SPCMIB), Université Paul Sabatier-Toulouse III/ CNRS (UMR5068), 118 route de Narbonne, F-31062 Toulouse, France. rivesarnaud1@yahoo.fr.
Fabien StauffertLaboratoire d'Innovation Moléculaire et Application (LIMA). Université de Strasbourg, Université de Haute-Alsace, CNRS (UMR 7042), Equipe Synthèse Organique et Molécules Bioactives (SYBIO), Ecole Européenne de Chimie, Polymères et Matériaux, 25 rue Becquerel, 67000 Strasbourg, France. fabien.stauffert@gmail.com.
Virginie GarciaInstitut National de la Santé et de la Recherche Médicale (INSERM) UMR1037, Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Paul Sabatier, Laboratoire de Biochimie Métabolique, Institut Fédératif de Biologie, CHU Purpan, F-31059 Toulouse, France. Virginie.Garcia@inserm.fr.
Thierry LevadeInstitut National de la Santé et de la Recherche Médicale (INSERM) UMR1037, Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Paul Sabatier, Laboratoire de Biochimie Métabolique, Institut Fédératif de Biologie, CHU Purpan, F-31059 Toulouse, France. thierry.levade@inserm.fr.
Philippe CompainLaboratoire d'Innovation Moléculaire et Application (LIMA). Université de Strasbourg, Université de Haute-Alsace, CNRS (UMR 7042), Equipe Synthèse Organique et Molécules Bioactives (SYBIO), Ecole Européenne de Chimie, Polymères et Matériaux, 25 rue Becquerel, 67000 Strasbourg, France. philippe.compain@unistra.fr.
Yves GénissonLaboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique (SPCMIB), Université Paul Sabatier-Toulouse III/ CNRS (UMR5068), 118 route de Narbonne, F-31062 Toulouse, France. genisson@chimie.ups-tlse.fr.
Centre National de la Recherche Scientifique · FRUniversité Toulouse III - Paul Sabatier · FR

Funding

Agence Nationale de la Recherche ShingoDRVaincre les Maladies Lysosomales Design of new polypharmacophoric dendrimers for an innovative dual therapeutic strategy for Gaucher disease
6 · The paper itself

Abstract

A series of simple

Indexed as

AnimalsCells, CulturedCeramidesEnzyme InhibitorsFibroblastsGlucosylceramidaseHumansHydrolysisImino PyranosesImino SugarsIsomerismLysosomesMelanoma, ExperimentalMiceMolecular Docking SimulationMolecular StructureCeramidesEnzyme InhibitorsGlucosylceramidaseImino PyranosesImino SugarsisofagominepiperidinePiperidinespyrrolidinePyrrolidinesGaucher diseaseglucocerebrosidaseglucosylceramide synthase inhibitorsglycosidase inhibitorsiminosugarsligand dockingpharmacological chaperones

Identifiers

PMID30669468
PMCPMC6359432
OpenAlexW2911029539

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.