Evidence map›Paper›PMID 30669451›Full record

ReviewCells2019

Telomere Biology and Human Phenotype.

Kara J Turner, Vimal Vasu, Darren K Griffin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 196 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
196citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

196 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  9. Trial
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  11. Association of nutraceutical supplements with longer telomere length.International journal of molecular medicine · 2019
    Trial
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136 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kara J TurnerUniversity of Kent, School of Biosciences, Giles Lane, Canterbury, Kent, CT2-7NJ, UK. k.j.turner-24@kent.ac.uk.
Vimal VasuUniversity of Kent, School of Biosciences, Giles Lane, Canterbury, Kent, CT2-7NJ, UK. vimal.vasu@nhs.net.ORCID 0000-0003-2606-9797
Darren K GriffinUniversity of Kent, School of Biosciences, Giles Lane, Canterbury, Kent, CT2-7NJ, UK. d.k.griffin@kent.ac.uk.ORCID 0000-0001-7595-3226

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Telomeres are nucleoprotein structures that cap the end of each chromosome arm and function to maintain genome stability. The length of telomeres is known to shorten with each cell division and it is well-established that telomere attrition is related to replicative capacity in vitro. Moreover, telomere loss is also correlated with the process of aging in vivo. In this review, we discuss the mechanisms that lead to telomere shortening and summarise telomere homeostasis in humans throughout a lifetime. In addition, we discuss the available evidence that shows that telomere shortening is related to human aging and the onset of age-related disease.

Indexed as

AgingDNA ReplicationHomeostasisHumansPhenotypeTelomereTelomere Homeostasisagingsenescencetelomere lengthtelomeres

Identifiers

PMID30669451
PMCPMC6356320

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.