Evidence map›Paper›PMID 30669445›Full record

ReviewMolecules (Basel, Switzerland)2019

Peptide-Based Drug-Delivery Systems in Biotechnological Applications: Recent Advances and Perspectives.

Diego Tesauro, Antonella Accardo, Carlo Diaferia, Vittoria Milano, Jean Guillon, Luisa Ronga, Filomena Rossi

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed.

  1. Review
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  9. Intracellular redistribution of cell-penetrating peptide p28: A mechanism for enhanced anti-cancer activity.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Article
  10. Review
  11. Article
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  19. mRNA vaccines and their delivery strategies: A journey from infectious diseases to cancer.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Review
  20. PEGylated insulin loaded complexation hydrogels for protected oral delivery.Journal of controlled release : official journal of the Controlled Release Society · 2023
    Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Diego TesauroDepartment of Pharmacy and CIRPeB, Università Federico II, 80134 Naples, Italy. diego.tesauro@unina.it.
Antonella AccardoDepartment of Pharmacy and CIRPeB, Università Federico II, 80134 Naples, Italy. antonella.accardo@unina.it.
Carlo DiaferiaDepartment of Pharmacy and CIRPeB, Università Federico II, 80134 Naples, Italy. carlo.diaferia@unina.it.ORCID 0000-0002-9273-0136
Vittoria MilanoDepartment of Pharmacy and CIRPeB, Università Federico II, 80134 Naples, Italy. vittoria.milano@unina.it.
Jean GuillonARNA, INSERM U1212/UMR CNRS 5320, UFR des Sciences Pharmaceutiques, Université de Bordeaux, F-33000 Bordeaux, France. jean.guillon@u-bordeaux.fr.ORCID 0000-0001-8577-3894
Luisa RongaInstitute of Analytical Sciences, IPREM, UMR 5254, CNRS-University of Pau, 64000 Pau, France. luisa.ronga@univ-pau.fr.
Filomena RossiDepartment of Pharmacy and CIRPeB, Università Federico II, 80134 Naples, Italy. filomena.rossi@unina.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peptides of natural and synthetic sources are compounds operating in a wide range of biological interactions. They play a key role in biotechnological applications as both therapeutic and diagnostic tools. They are easily synthesized thanks to solid-phase peptide devices where the amino acid sequence can be exactly selected at molecular levels, by tuning the basic units. Recently, peptides achieved resounding success in drug delivery and in nanomedicine smart applications. These applications are the most significant challenge of recent decades: they can selectively deliver drugs to only pathological tissues whilst saving the other districts of the body. This specific feature allows a reduction in the drug side effects and increases the drug efficacy. In this context, peptide-based aggregates present many advantages, including biocompatibility, high drug loading capacities, chemical diversity, specific targeting, and stimuli responsive drug delivery. A dual behavior is observed: on the one hand they can fulfill a structural and bioactive role. In this review, we focus on the design and the characterization of drug delivery systems using peptide-based carriers; moreover, we will also highlight the peptide ability to self-assemble and to actively address nanosystems toward specific targets.

Indexed as

Amino AcidsBiological TransportDipeptidesDrug Delivery SystemsDrug LiberationHumansMolecular Targeted TherapyNanomedicineNanostructuresPeptidesPhenylalanineProtein MultimerizationAmino AcidsDipeptidesPeptidesPhenylalaninephenylalanylphenylalanineactive targeting receptorsbinding peptidesdiphenylalaninedrug deliverypeptidepeptide backbone structurespeptide self-assembling carriers

Identifiers

PMID30669445
PMCPMC6359574

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.