Evidence map›Paper›PMID 30669443›Full record

ArticleCells2019

Functional Characterization of Ubiquitin-Like Core Autophagy Protein ATG12 in

Sarah Fischer, Ramesh Rijal, Peter Frommolt, Prerana Wagle, Roman Konertz, Jan Faix, Susanne Meßling, Ludwig Eichinger

Open access · goldAbstract read
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  8. RNABMC genomics · 2021
    Article
  9. TheFrontiers in cell and developmental biology · 2021
    Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Sarah FischerInstitute of Biochemistry I, Medical Faculty, University Hospital Cologne, 50931 Cologne, Germany. sarah.fischer@uni-koeln.de.
Ramesh RijalDepartment of Biology, Texas A & M University, Laredo, TX 77843-3474, USA. rrijal@bio.tamu.edu.ORCID 0000-0003-0498-1064
Peter FrommoltBioinformatics Core Facility, CECAD Research Center, University Hospital Cologne, 50931 Cologne, Germany. peter.frommolt@t-online.de.
Prerana WagleBioinformatics Core Facility, CECAD Research Center, University Hospital Cologne, 50931 Cologne, Germany. prerana.wagle@uk-koeln.de.
Roman KonertzInstitute of Biochemistry I, Medical Faculty, University Hospital Cologne, 50931 Cologne, Germany. rkonertz@uni-koeln.de.ORCID 0000-0002-6488-1885
Jan FaixInstitute for Biophysical Chemistry, Hannover Medical School, 30625 Hannover, Germany. faix.jan@mh-hannover.de.
Susanne MeßlingInstitute of Biochemistry I, Medical Faculty, University Hospital Cologne, 50931 Cologne, Germany. susanne_messling@web.de.
Ludwig EichingerInstitute of Biochemistry I, Medical Faculty, University Hospital Cologne, 50931 Cologne, Germany. ludwig.eichinger@uni-koeln.de.ORCID 0000-0003-1594-6117
University Hospital Cologne · DECologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases · DEMedizinische Hochschule Hannover · DETexas A&M International University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagy is a highly conserved intracellular degradative pathway that is crucial for cellular homeostasis. During autophagy, the core autophagy protein ATG12 plays, together with ATG5 and ATG16, an essential role in the expansion of the autophagosomal membrane. In this study we analyzed gene replacement mutants of

Indexed as

AutophagyAmino Acid SequenceAutophagy-Related Protein 12Cell SurvivalConserved SequenceDictyosteliumEndocytosisEvolution, MolecularGene Expression RegulationGene OntologyLysosomesMutationNitrogenProteostasisAutophagy-Related Protein 12NitrogenATG12ATG16autophagyDictyosteliumphagocytosispinocytosispost-translational modifierproteasomeubiquitin-like proteinubiquitin proteasome system (UPS)

Identifiers

PMID30669443
PMCPMC6356199
OpenAlexW2911096180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.