ArticleSensors (Basel, Switzerland)2019
Cortical Network Response to Acupuncture and the Effect of the Hegu Point: An fNIRS Study.
Article in Sensors (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 60 citations in OpenAlex.
- LR3-LI4 needling side and configuration are associated with phase-specific cortical activation and network organization: a functional near-infrared spectroscopy study in healthy adults.Frontiers in neurology · 2026Trial
- The increased inter-brain neural synchronization in prefrontal cortex between simulated patient and acupuncturist during acupuncture stimulation: Evidence from functional near-infrared spectroscopy hyperscanning.Human brain mapping · 2023Trial
- Connectivity-Based Pain Recognition from fNIRS: Parsimonious Subject-Independent Classification.Sensors (Basel, Switzerland) · 2026Article
- Article
- Neural Mechanism of Cognitive Reserve in Acupuncture Stimulation: Protocol for a Randomized, Placebo-Controlled Functional Near-Infrared Spectroscopy Trial.JMIR research protocols · 2025Article
- When sng meets acupuncture -- a paradigm-shift biomarker for translational research.Journal of traditional and complementary medicine · 2025Review
- Analysis of the application of functional near-infrared spectroscopy in acupuncture research: a review.Frontiers in neurology · 2025Review
- Multilevel Pain Assessment with Functional Near-Infrared Spectroscopy: Evaluating ΔSensors (Basel, Switzerland) · 2024Article
- Exploring feasibility of fNIRS to assess delayed inhibition effect of prefrontal cortex for acute stress by acupuncture on GV20: a pilot study.Frontiers in human neuroscience · 2024Article
- Global trends and performances of infrared imaging technology studies on acupuncture: a bibliometric analysis.Frontiers in neuroscience · 2024Review
- Empirical comparison of deep learning models for fNIRS pain decoding.Frontiers in neuroinformatics · 2024Article
- A systematic review of neurophysiological sensing for the assessment of acute pain.NPJ digital medicine · 2023Review
- Experimental Exploration of Multilevel Human Pain Assessment Using Blood Volume Pulse (BVP) Signals.Sensors (Basel, Switzerland) · 2023Article
- Applications of functional near-infrared spectroscopy in non-drug therapy of traditional Chinese medicine: a review.Frontiers in neuroscience · 2023Review
- Effect of Acupuncture on Postoperative Pain in Patients after Laparoscopic Cholecystectomy: A Randomized Clinical Trial.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Self-administered transcranial direct current stimulation treatment of knee osteoarthritis alters pain-related fNIRS connectivity networks.Neurophotonics · 2023Article
- The regulations on cortical activation and functional connectivity of the dorsolateral prefrontal cortex-primary somatosensory cortex elicited by acupuncture with reinforcing-reducing manipulation.Frontiers in human neuroscience · 2023Article
- Multimodal physiological sensing for the assessment of acute pain.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Real-Time Hemodynamic Changes in the Prefrontal and Bilateral Temporal Cortices During Intradermal Acupuncture for Major Depressive Disorder: A Prospective, Single-Center, Controlled Trial Protocol.Neuropsychiatric disease and treatment · 2023Article
- EEG-Validated Photobiomodulation Treatment of Dementia-Case Study.Sensors (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acupuncture is a practice of treatment based on influencing specific points on the body by inserting needles. According to traditional Chinese medicine, the aim of acupuncture treatment for pain management is to use specific acupoints to relieve excess, activate qi (or vital energy), and improve blood circulation. In this context, the Hegu point is one of the most widely-used acupoints for this purpose, and it has been linked to having an analgesic effect. However, there exists considerable debate as to its scientific validity. In this pilot study, we aim to identify the functional connectivity related to the three main types of acupuncture manipulations and also identify an analgesic effect based on the hemodynamic response as measured by functional near-infrared spectroscopy (fNIRS). The cortical response of eleven healthy subjects was obtained using fNIRS during an acupuncture procedure. A multiscale analysis based on wavelet transform coherence was employed to assess the functional connectivity of corresponding channel pairs within the left and right somatosensory region. The wavelet analysis was focused on the very-low frequency oscillations (VLFO, 0.01⁻0.08 Hz) and the low frequency oscillations (LFO, 0.08⁻0.15 Hz). A mixed model analysis of variance was used to appraise statistical differences in the wavelet domain for the different acupuncture stimuli. The hemodynamic response after the acupuncture manipulations exhibited strong activations and distinctive cortical networks in each stimulus. The results of the statistical analysis showed significant differences ( p < 0.05 ) between the tasks in both frequency bands. These results suggest the existence of different stimuli-specific cortical networks in both frequency bands and the anaesthetic effect of the Hegu point as measured by fNIRS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.