Evidence map›Paper›PMID 30669280›Full record

Trial reportNutrients2019

The Effect of Vitamin D Supplementation on Hepcidin, Iron Status, and Inflammation in Pregnant Women in the United Kingdom.

Vickie S Braithwaite, Sarah R Crozier, Stefania D'Angelo, Ann Prentice, Cyrus Cooper, Nicholas C Harvey, Kerry S Jones, MAVIDOS Trial Group

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2024
    Pooled it
  2. Pooled it
  3. The Effect of Vitamin DInternational journal of environmental research and public health · 2020
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Vickie S BraithwaiteMRC Elsie Widdowson Laboratory, Cambridge CB1 9NL, UK. vb287@cam.ac.uk.ORCID 0000-0002-3366-2903
Sarah R CrozierMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. src@mrc.soton.ac.uk.ORCID 0000-0002-9524-1127
Stefania D'AngeloMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. sd@mrc.soton.ac.uk.
Ann PrenticeMRC Elsie Widdowson Laboratory, Cambridge CB1 9NL, UK. ann.prentice@mrc-lmb.cam.ac.uk.
Cyrus CooperMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. cc@mrc.soton.ac.uk.ORCID 0000-0003-3510-0709
Nicholas C HarveyMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. nch@mrc.soton.ac.uk.
Kerry S JonesMRC Elsie Widdowson Laboratory, Cambridge CB1 9NL, UK. kerry.jones@mrc-epid.cam.ac.uk.
MAVIDOS Trial Group
Southampton General Hospital · GBMRC Human Nutrition Research · GB

Funding

Department of Health 10/33/04Department of Health HTA/10/33/04Medical Research Council G0400491Medical Research Council G0601019Medical Research Council MC_U105960371Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_U147585827Medical Research Council MC_UP_A620_1014Medical Research Council MC_UP_A620_1015Medical Research Council MC_UU_12011/1Medical Research Council MC_UU_12011/2Versus Arthritis 17702Versus Arthritis 19583Versus Arthritis 21231
6 · The paper itself

Abstract

Iron and vitamin D deficiencies are common during pregnancy. Our aim was to identify whether antenatal vitamin D₃ supplementation affects iron status (via hepcidin suppression) and/or inflammation. Using a subset of the UK multicenter Maternal Vitamin D Osteoporosis Study (MAVIDOS)-a double-blinded, randomized, placebo-controlled trial (ISRCTN82927713; EudraCT2007-001716-23)-we performed a secondary laboratory analysis. Women with blood samples from early and late pregnancy (vitamin D₃ (1000 IU/day from ~14 weeks gestation

Indexed as

Anemia, Iron-DeficiencyInflammationAdultCholecalciferolC-Reactive ProteinDietary SupplementsDouble-Blind MethodFemaleFerritinsHepcidinsHumansIronNutritional StatusPregnancyPregnancy ComplicationsPregnancy Trimesters25-hydroxyvitamin DCholecalciferolC-Reactive ProteinFerritinsHepcidinsIronVitamin DC-reactive proteinferritinhepcidininflammationpregnancyVitamin D

Identifiers

PMID30669280
PMCPMC6356300
OpenAlexW2910974504

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.