Observational studyAmerican journal of nephrology2019
Cortical Perfusion and Tubular Function as Evaluated by Magnetic Resonance Imaging Correlates with Annual Loss in Renal Function in Moderate Chronic Kidney Disease.
Observational study in American journal of nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07175051 (Targeting the Pathophysiology of Sickle Cell-Related Kidney Disease Using the SGLT2 Inhibitors, Empagliflozin), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Targeting the Pathophysiology of Sickle Cell-Related Kidney Disease Using the SGLT2 Inhibitors, Empagliflozin
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Functional magnetic resonance imaging for staging chronic kidney disease: a systematic review and meta-analysis.International urology and nephrology · 2024Pooled it
- Overweight and Obesity Are Associated with Lower Renal Blood Flow in Autosomal Dominant Polycystic Kidney Disease.Kidney & blood pressure research · 2026Trial
- Prostacyclin analog beraprost sodium efficacy in primary glomerular disease or nephrosclerosis: Analysis of the Japanese subgroup in CASSIOPEIR study.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2021Trial
- Association of CT-based perirenal structural characteristics with chronic kidney disease risk categories: the additional value of imaging.Acta diabetologica · 2026Article
- Physiological confounders of renal blood flow measurement.Magma (New York, N.Y.) · 2024Review
- Fibrosis in Chronic Kidney Disease: Pathophysiology and Therapeutic Targets.Journal of clinical medicine · 2024Review
- An arterial spin labeling-based radiomics signature and machine learning for the prediction and detection of various stages of kidney damage due to diabetes.Frontiers in endocrinology · 2024Article
- Multiparametric Renal Magnetic Resonance Imaging for Prediction and Annual Monitoring of the Progression of Chronic Kidney Disease over Two Years.Journal of clinical medicine · 2023Article
- Renal Perfusion, Oxygenation and Metabolism: The Role of Imaging.Journal of clinical medicine · 2023Review
- Magnetic Resonance Imaging in Clinical Trials of Diabetic Kidney Disease.Journal of clinical medicine · 2023Review
- mDIXON-Quant for differentiation of renal damage degree in patients with chronic kidney disease.Frontiers in endocrinology · 2023Article
- Kidney oxygenation, perfusion and blood flow in people with and without type 1 diabetes.Clinical kidney journal · 2022Article
- Multiparametric magnetic resonance imaging allows non-invasive functional and structural evaluation of diabetic kidney disease.Clinical kidney journal · 2022Article
- Radiomics-Based Image Phenotyping of Kidney Apparent Diffusion Coefficient Maps: Preliminary Feasibility & Efficacy.Journal of clinical medicine · 2022Article
- Basic principles and new advances in kidney imaging.Kidney international · 2021Review
- Diffusion tensor imaging for the study of early renal dysfunction in patients affected by bardet-biedl syndrome.Scientific reports · 2021Article
- Detection of renal allograft fibrosis with MRI: arterial spin labeling outperforms reduced field-of-view IVIM.European radiology · 2021Article
- Cardiorenal Syndrome: Emerging Role of Medical Imaging for Clinical Diagnosis and Management.Journal of personalized medicine · 2021Review
- Perspectives on the Role of Magnetic Resonance Imaging (MRI) for Noninvasive Evaluation of Diabetic Kidney Disease.Journal of clinical medicine · 2021Review
- Early detection of subclinical pathology in patients with stable kidney graft function by arterial spin labeling.European radiology · 2021Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundChronic hypoxia is a well-recognized factor in the pathogenesis of chronic kidney disease (CKD). Loss of microcirculation is thought to lead to enhanced renal hypoxia, which in turn results in the development of fibrosis, a hallmark of progressive CKD. To evaluate the role of functional magnetic resonance imaging (MRI), we performed perfusion, oxygenation, and diffusion MRI measurements in individuals with diabetes and stage 3 CKD.
methodsFifty-four subjects (41 individuals with diabetes and stage 3 CKD and 13 healthy controls) participated in this study. Data with blood oxygenation level dependent (BOLD), arterial spin labeling perfusion and diffusion MRI were acquired using a 3T scanner.
resultsRenal cortical perfusion was reduced in CKD compared to the controls (109.54 ± 25.38 vs. 203.17 ± 27.47 mL/min/100 g; p < 0.001). Cortical apparent diffusion coefficient showed no significant reduction in CKD compared to controls (1,596.10 ± 196.64 vs. 1,668.72 ± 77.29 × 10-6 mm2/s; p = 0.45) but was significantly associated with perfusion. Cortical R2* values were modestly increased in CKD (20.76 ± 4.08 vs. 18.74 ± 2.37 s-1; p = 0.12). Within the CKD group, R2*_Medulla and R2*_Kidney were moderately and negatively associated with estimated glomerular filtration rate. There was a significant association between cortical perfusion and medullary response to furosemide with annual loss of renal function, used as an estimate of CKD progression.
conclusionsSubjects with a moderate degree of CKD had significantly lower renal perfusion. Diffusion and BOLD MRI showed more modest differences between the groups. Individuals with progressive CKD had lower perfusion and response to furosemide.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.