Evidence map›Paper›PMID 30669119›Full record

ArticleAging2019

DNA methylation GrimAge strongly predicts lifespan and healthspan.

Ake T Lu, Austin Quach, James G Wilson, Alex P Reiner, Abraham Aviv, Kenneth Raj, Lifang Hou, Andrea A Baccarelli, Yun Li, James D Stewart and 4 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06357663 (Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Telomere Length in Peripheral Blood Leukocytes A Follow-up Pilot Study), which is not on this map. Cited by 1,607 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,607citing papers in PubMed, 3 pooled it
67.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06357663 naterminatednot on this mapstarted 2023, after this paper: background citation

Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Telomere Length in Peripheral Blood Leukocytes A Follow-up Pilot Study

TypeinterventionalSponsorSha Research FoundationRan2023 to 2025Enrolled12ConditionsTelomere Length, Quality of LifeArmsMindfulness practice with Calligraphy
3 · Its place in the literature

Who cites it

1,607 citing papers in PubMed, 3 syntheses or guidelines pooled it, 2,454 citations in OpenAlex.

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1,547 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 2 countries.

Ake T LuDepartment of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Austin QuachDepartment of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Alex P ReinerPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Abraham AvivCenter of Development and Aging, New Jersey Medical School, Rutgers State University of New Jersey, Newark, NJ 07103, USA.
Kenneth RajRadiation Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot, Oxfordshire OX11 0RQ, United Kingdom.
Lifang HouCenter for Population Epigenetics, Robert H. Lurie Comprehensive Cancer Center and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Andrea A BaccarelliLaboratory of Environmental Epigenetics, Departments of Environmental Health Sciences Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA.
Yun LiDepartments of Genetics, Biostatistics, Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA.
James D StewartDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA.
Eric A WhitselDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA.
Themistocles L AssimesDepartment of Medicine (Division of Cardiovascular Medicine), Stanford University School of Medicine, Stanford, CA 94305, USA.
Luigi FerrucciLongitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, USA, Baltimore, MD 21224, USA.
Steve HorvathDepartment of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
University of California, Los Angeles · USUniversity of North Carolina at Chapel Hill · USColumbia University · USFred Hutch Cancer Center · USNational Institute on Aging · USPublic Health England · GBRobert H. Lurie Comprehensive Cancer Center of Northwestern UniversityRutgers New Jersey Medical SchoolStanford University · USUniversity of Mississippi Medical Center · US

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, JOHN E · 2016 to 2025
$38.2M
Validation and optimization of epigenetic clocksU01AG060908 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2018 to 2022
$3.4M
Leukocyte Telomere Length and Cardiovascular Disease in Jackson Heart StudyR01HL116446 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI AVIV, ABRAHAM, REINER, ALEXANDER P · 2013 to 2016
$3.1M
Epigenetic Mechanisms of PM-Mediated CVD RiskR01ES020836 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BACCARELLI, ANDREA, HOU, LIFANG · 2012 to 2016
$3.0M
Exceptional Aging Across the Life Span: Framingham StudyR01AG029451 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MURABITO, JOANNE M · 2008 to 2011
$1.3M
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
NHLBI NIH HHS HHSN268201300046CNHLBI NIH HHS HHSN268201300047CNHLBI NIH HHS HHSN268201300048CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS HHSN268201300050CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL116446NIA NIH HHS R01 AG029451NIA NIH HHS U01 AG060908NIEHS NIH HHS R01 ES020836NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

It was unknown whether plasma protein levels can be estimated based on DNA methylation (DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful predictor of lifespan. We present here, seven DNAm-based estimators of plasma proteins including those of plasminogen activator inhibitor 1 (PAI-1) and growth differentiation factor 15. The resulting predictor of lifespan, DNAm GrimAge (in units of years), is a composite biomarker based on the seven DNAm surrogates and a DNAm-based estimator of smoking pack-years. Adjusting DNAm GrimAge for chronological age generated novel measure of epigenetic age acceleration,

Indexed as

AgingBlood ProteinsDNA MethylationLongevityAdipose TissueBiomarkersDatabases, FactualDietDietary SupplementsEducationFatty Acids, Omega-3FemaleHumansLife StyleLongitudinal StudiesMaleBiomarkersBlood ProteinsFatty Acids, Omega-3DNA methylationepigeneticsmortalityproteomics

Identifiers

PMID30669119
PMCPMC6366976
OpenAlexW2912654909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.