Evidence map›Paper›PMID 30669015›Full record

ArticleBiomaterials2019

A new class of biological materials: Cell membrane-derived hydrogel scaffolds.

Zhiyuan Fan, Junjie Deng, Peter Y Li, Daphney R Chery, Yunfei Su, Pu Zhu, Taku Kambayashi, Elizabeth P Blankenhorn, Lin Han, Hao Cheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 71 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Red blood cells: a potential delivery system.Journal of nanobiotechnology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Zhiyuan FanDepartment of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USA.
Junjie DengDepartment of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USA; School of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325011, China; Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences, Wenzhou, Zhejiang 325000, China.
Peter Y LiDepartment of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USA.
Daphney R CherySchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA.
Yunfei SuSchool of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325011, China; Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences, Wenzhou, Zhejiang 325000, China.
Pu ZhuDepartment of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USA.
Taku KambayashiDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Elizabeth P BlankenhornDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA.
Lin HanSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA.
Hao ChengDepartment of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USA; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA. Electronic address: hcheng@drexel.edu.
Drexel University · USAffiliated Eye Hospital of Wenzhou Medical College · CNUniversity of Pennsylvania · USWenzhou Medical University · CN

Funding

Injectable Biomaterial Scaffold for Inducing Antigen-Specific ToleranceR21AI133372 · NIAID · DREXEL UNIVERSITY · PI BLANKENHORN, ELIZABETH P, CHENG, HAO · 2017 to 2018
$430k
NIAID NIH HHS R21 AI133372
6 · The paper itself

Abstract

Biological materials are superior to synthetic biomaterials in biocompatibility and active interactions with cells. Here, a new class of biological materials, cell membrane-derived hydrogel scaffolds are reported for harnessing these advantages. To form macroporous scaffolds, vesicles derived from red blood cell membranes (RBCMs) are chemically crosslinked via cryogelation. The RBCM scaffolds with a pore size of around 70 μm are soft and injectable. Highly biocompatible scaffolds are typically made of superhydrophilic polymers and lack the ability to encapsulate and release hydrophobic drugs in a controlled manner. However, hydrophobic molecules can be efficiently encapsulated inside RBCM scaffolds and be sustainedly released. RBCM scaffolds show low neutrophil infiltration after subcutaneous injection in mice, and a significantly higher number of infiltrated macrophages than methacrylate alginate (MA-alginate) scaffolds. According to gene expression and surface markers, these macrophages have an M2-like phenotype, which is anti-inflammatory and immune suppressive. There are also higher percentages of macrophages presenting immunosuppressive PD-L1 in RBCM-scaffolds than in MA-alginate scaffolds. Interestingly, the concentrations of anti-inflammatory cytokine, IL-10 in both types of scaffolds are higher than those in normal organ tissues. This study sheds light on cell membrane-derived hydrogels, which can actively modulate cells in unique ways unavailable to existing hydrogel scaffolds.

Indexed as

AnimalsBiocompatible MaterialsCells, CulturedDelayed-Action PreparationsErythrocyte MembraneFemaleMacrophagesMice, Inbred C57BLPyrenesTissue EngineeringTissue ScaffoldsBiocompatible MaterialsDelayed-Action PreparationspyrenePyrenesDrug deliveryImmune modulationImmunoengineeringRegenerative medicineTissue regeneration

Identifiers

PMID30669015
PMCPMC6369705
OpenAlexW2910433925

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.