Evidence map›Paper›PMID 30668980›Full record

ArticleBrain, behavior, and immunity2019

Prenatal and early life diesel exhaust exposure disrupts cortical lamina organization: Evidence for a reelin-related pathogenic pathway induced by interleukin-6.

Yu-Chi Chang, Ray Daza, Robert Hevner, Lucio G Costa, Toby B Cole

Open access · greenAbstract read
In one paragraph

Article in Brain, behavior, and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Air Pollution-Related Neurotoxicity Across the Life Span.Annual review of pharmacology and toxicology · 2023
    Review
  11. Air Pollution: Possible Interaction between the Immune and Nervous System?International journal of environmental research and public health · 2022
    Review
  12. Review
  13. Autism-like symptoms by exposure to air pollution and valproic acid-induced in male rats.Environmental science and pollution research international · 2022
    Article
  14. Passage of exogeneous fine particles from the lung into the brain in humans and animals.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. News Feature: How air pollution threatens brain health.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Yu-Chi ChangDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA. Electronic address: ycc2@uw.edu.
Ray DazaCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA. Electronic address: ray.daza@seattlechildrens.org.
Robert HevnerCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA; Department of Neurological Surgery, University of Washington, Seattle, WA, USA. Electronic address: rhevner@uw.edu.
Lucio G CostaDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA; Department of Medicine and Surgery, University of Parma, Parma, Italy. Electronic address: lgcosta@uw.edu.
Toby B ColeDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA; Center on Human Development and Disability, University of Washington, Seattle, WA, USA. Electronic address: tobycole@uw.edu.
University of Washington · USNeurological Surgery · USUniversity of Parma · IT

Funding

WILDLIFE BIOMARKER APPLICATIONS TO REMEDIATION DECISION MAKINGP42ES004696 · NIEHS · UNIVERSITY OF WASHINGTON · PI FURLONG, CLEMENT EUGENE · 1987 to 2021
$51.2M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Sheela Sathyanarayana · 1995 to 2026
$42.5M
Intellectual and Developmental Disabilities Research CenterU54HD083091 · NICHD · UNIVERSITY OF WASHINGTON · PI MARAVILLA, KENNETH R · 2014 to 2019
$7.9M
Intermediate neuronal progenitors in neocortical developmentR01NS085081 · NINDS · SEATTLE CHILDREN'S HOSPITAL · PI HEVNER, ROBERT F · 2013 to 2017
$2.1M
Gene-environment interactions in the developmental neurotoxicity of air pollutionR01ES028273 · NIEHS · UNIVERSITY OF WASHINGTON · PI COSTA, LUCIO G · 2017 to 2021
$2.0M
Development and Malformations of the Dentate GyrusR01NS092339 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HEVNER, ROBERT F · 2016 to 2020
$1.9M
Air pollution and the brain: gender as an important determinant of susceptibilityR01ES022949 · NIEHS · UNIVERSITY OF WASHINGTON · PI COSTA, LUCIO G · 2013 to 2017
$1.7M
NICHD NIH HHS U54 HD083091NIEHS NIH HHS P30 ES007033NIEHS NIH HHS P42 ES004696NIEHS NIH HHS R01 ES022949NIEHS NIH HHS R01 ES028273NINDS NIH HHS R01 NS085081NINDS NIH HHS R01 NS092339
6 · The paper itself

Abstract

Several epidemiological studies have shown associations between developmental exposure to traffic-related air pollution and increased risk for autism spectrum disorders (ASD), a spectrum of neurodevelopmental disorders with increasing prevalence rate in the United States. Though animal studies have provided support for these associations, little is known regarding possible underlying mechanisms. In a previous study we found that exposure of C57BL/6J mice of both sexes to environmentally relevant levels (250-300 µg/m

Indexed as

Air PollutantsAnimalsBrainCalbindin 2Cell Adhesion Molecules, NeuronalCerebral CortexExtracellular Matrix ProteinsFemaleInhalation ExposureInterleukin-6MaleMiceMice, Inbred C57BLNerve Tissue ProteinsPrefrontal CortexPregnancyAir PollutantsCalbindin 2Cell Adhesion Molecules, NeuronalExtracellular Matrix ProteinsInterleukin-6Nerve Tissue ProteinsReelin ProteinRELN protein, humanReln protein, mouseSerine EndopeptidasesVehicle EmissionsAir pollutionAutism spectrum disorderCortical lamina organizationDiesel exhaustMiceNeuroinflammationReelin

Identifiers

PMID30668980
PMCPMC6557404
OpenAlexW2910804729

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.