Evidence map›Paper›PMID 30668956›Full record

ReviewMechanisms of ageing and development2019

Tauopathy: A common mechanism for neurodegeneration and brain aging.

Pampa Saha, Nilkantha Sen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Mechanisms of ageing and development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it, 131 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Reversibility and β-sheet formation are decoupled in tau condensate aging.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Exploring the effect of gut microbiome on Alzheimer's disease.Biochemistry and biophysics reports · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Tau Protein Alterations Induced by Hypobaric Hypoxia Exposure.International journal of molecular sciences · 2024
    Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Pampa SahaDepartment of Neurological Surgery, University of Pittsburgh, 200 Lothrop Street, Scaife Hall, Pittsburgh, 15213, United States.
Nilkantha SenDepartment of Neurological Surgery, University of Pittsburgh, 200 Lothrop Street, Scaife Hall, Pittsburgh, 15213, United States. Electronic address: senn@pitt.edu.
Neurological Surgery · US

Funding

Molecular Mechanisms underlying vision impairment after TBIR01EY025622 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SEN, NILKANTHA · 2016 to 2020
$1.9M
Development of therapeutic strategy against TBI based on hydrogen sulfideR01NS094516 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SEN, NILKANTHA · 2016 to 2020
$1.7M
NEI NIH HHS R01 EY025622NINDS NIH HHS R01 NS094516
6 · The paper itself

Abstract

Tau, a microtubule-associated protein promotes assembly and stability of microtubules which is related to axoplasmic flow and critical neuronal activities upon physiological conditions. Under neurodegenerative condition such as in Alzheimer's Disease (AD), tau-microtubule binding dynamics and equilibrium are severely affected due to its aberrant post-translational modifications including acetylation and hyperphosphorylation. This event results in its conformational changes to form neurofibrillary tangles (NFT) after aggregation in the cytosol. The formation of NFT is more strongly correlated with cognitive decline than the distribution of senile plaque, which is formed by polymorphous beta-amyloid (Aβ) protein deposits, another pathological hallmark of AD. In neurodegenerative conditions, other than AD, the disease manifestation is correlated with mutations of the MAPT gene. In Primary age-related tauopathy (PART), which is commonly observed in the brains of aged individuals, tau deposition is directly correlated with cognitive deficits even in the absence of Aβ deposition. Thus, tauopathy has been considered as an essential hallmark in neurodegeneration and normal brain aging. In this review, we highlighted the recent progress about the tauopathies in the light of its posttranslational modifications and its implication in AD and the aged brain.

Indexed as

Protein Processing, Post-TranslationalAcetylationAgingAlzheimer DiseaseAmyloid beta-PeptidesBrainCognitive DysfunctionHumansNeurofibrillary TanglesOxidative StressPhosphorylationPlaque, AmyloidTauopathiestau ProteinsAmyloid beta-Peptidestau ProteinsAgingAlzheimer’s diseaseAmyloid betaCognitive dysfunctionNeurodegenerationTau acetylationTau hyperphosphorylationTauopathy

Identifiers

PMID30668956
PMCPMC6377302
OpenAlexW2909203784

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.