Developmental Biology: Hox Timing Determines Limb Placement.

John J Young, Phil Grayson, Clifford J Tabin

Open access · bronzeAbstract readComment

In one paragraph

Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

0.5field-weighted citation impact, top 36% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

Loss of wbp11 causes multi-system developmental defects: a zebrafish model of VACTERL association.Frontiers in cell and developmental biology · 2026
Article
Congenital Malformations in Sea Turtles: Puzzling Interplay between Genes and Environment.Animals : an open access journal from MDPI · 2021
Review
HOX gene cluster (de)regulation in brain: from neurodevelopment to malignant glial tumours.Cellular and molecular life sciences : CMLS · 2020
Review
Accelerated Evolution of Limb-Related GeneG3 (Bethesda, Md.) · 2020
Article

4 · The record

Corrections and comments

Comment on
Timed Collinear Activation of Hox Genes during Gastrulation Controls the Avian Forelimb Position.2019

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

John J YoungDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.

Phil GraysonDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

Clifford J TabinDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address: tabin@genetics.med.harvard.edu.

Harvard University · US

Funding

The reprogramming of limb progenitor cellsR01HD032443 · NICHD · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI CLIFFORD J. TABIN · 1995 to 2026

$4.6M

NICHD NIH HHS R01 HD032443

6 · The paper itself

Abstract

Hox genes are known to determine vertebral identity along with being required for normal limb patterning. A new study now finds that differential expression timing of Hox genes in the lateral plate mesoderm determines limb placement as well.

Indexed as

GastrulationGenes, HomeoboxAnimalsBody PatterningDevelopmental BiologyForelimbGene Expression Regulation, DevelopmentalMesoderm

Identifiers

PMID30668947

DOI10.1016/j.cub.2018.11.068

OpenAlexW2913840762

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.