ArticleCerebral cortex (New York, N.Y. : 1991)2019
Thalamocortical Afferents Innervate the Cortical Subplate much Earlier in Development in Primate than in Rodent.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Early-life medial pulvinar disruption drives schizophrenia-relevant prefrontal inhibitory and cognitive deficits in primates.bioRxiv : the preprint server for biology · 2026Article
- Two gradients, one cortex.National science review · 2026Article
- Thalamus-cortex interactions drive cell type-specific cortical development in human pluripotent stem cell-derived assembloids.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
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- Neuronal activity modulates the expression of secretagogin, a CaActa physiologica (Oxford, England) · 2025Article
- Development of the early fetal human thalamus: from a protomap to emergent thalamic nuclei.Frontiers in neuroanatomy · 2025Article
- Development of the basic architecture of neocortical circuitry in the human fetus as revealed by the coupling spatiotemporal pattern of synaptogenesis along with microstructure and macroscale in vivo MR imaging.Brain structure & function · 2024Article
- A sensorimotor-association axis of thalamocortical connection development.bioRxiv : the preprint server for biology · 2024Article
- Spatial Single-cell Analysis Decodes Cortical Layer and Area Specification.bioRxiv : the preprint server for biology · 2024Article
- Artificial Intelligence: Fundamentals and Breakthrough Applications in Epilepsy.Epilepsy currents · 2024Review
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- Dendritic Spines: Synaptogenesis and Synaptic Pruning for the Developmental Organization of Brain Circuits.Advances in neurobiology · 2023Article
- Cortico-thalamic development and disease: From cells, to circuits, to schizophrenia.Frontiers in neuroanatomy · 2023Review
- Tyramide signal amplification coupled with multiple immunolabeling and RNAScope in situ hybridization in formaldehyde-fixed paraffin-embedded human fetal brain.Journal of anatomy · 2022Article
- The Role of Inhibitory Interneurons in Circuit Assembly and Refinement Across Sensory Cortices.Frontiers in neural circuits · 2022Review
- Early development of the cortical layers in the human brain.Journal of anatomy · 2021Article
- Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia.Nature neuroscience · 2021Article
- Advancing Autism Research From Mice to Marmosets: Behavioral Development of Offspring Following Prenatal Maternal Immune Activation.Frontiers in psychiatry · 2021Article
- Spatiotemporal Differences in the Regional Cortical Plate and Subplate Volume Growth during Fetal Development.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
The current model, based on rodent data, proposes that thalamocortical afferents (TCA) innervate the subplate towards the end of cortical neurogenesis. This implies that the laminar identity of cortical neurons is specified by intrinsic instructions rather than information of thalamic origin. In order to determine whether this mechanism is conserved in the primates, we examined the growth of thalamocortical (TCA) and corticofugal afferents in early human and monkey fetal development. In the human, TCA, identified by secretagogin, calbindin, and ROBO1 immunoreactivity, were observed in the internal capsule of the ventral telencephalon as early as 7-7.5 PCW, crossing the pallial/subpallial boundary (PSB) by 8 PCW before the calretinin immunoreactive corticofugal fibers do. Furthermore, TCA were observed to be passing through the intermediate zone and innervating the presubplate of the dorsolateral cortex, and already by 10-12 PCW TCAs were occupying much of the cortex. Observations at equivalent stages in the marmoset confirmed that this pattern is conserved across primates. Therefore, our results demonstrate that in primates, TCAs innervate the cortical presubplate at earlier stages than previously demonstrated by acetylcholinesterase histochemistry, suggesting that pioneer thalamic afferents may contribute to early cortical circuitry that can participate in defining cortical neuron phenotypes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.