ArticleAmerican journal of epidemiology2019
Comparison of the Associations of Early-Life Factors on Wheezing Phenotypes in Preterm-Born Children and Term-Born Children.
Article in American journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Machine learning-derived asthma and allergy trajectories in children: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Fractional exhaled nitric oxide in preterm-born subjects: A systematic review and meta-analysis.Pediatric pulmonology · 2019Pooled it
- Human milk feeding and wheeze in Black infants born preterm.Journal of perinatology : official journal of the California Perinatal Association · 2022Trial
- Association between intermittent hypoxemia and COVID-19 related isolation and pulmonary outcomes through 2 years of age in infants born preterm.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Acoustic and Perceptual Profiles of Swallowing Sounds in Preterm Neonates: A Cross-Sectional Study Cohort.Dysphagia · 2025Article
- Intra-breath respiratory mechanics of prematurity-associated lung disease phenotypes in school-aged children.ERJ open research · 2025Article
- Maternal exposure to smoking and wheezing phenotypes in children: a cohort study of the Japan Environment and Children's Study.BMC pediatrics · 2024Article
- Peripheral airway dysfunction in prematurity-associated obstructive lung disease identified by oscillometry.Pediatric pulmonology · 2023Article
- Clinical predictors of wheeze trajectories and associations with allergy in Asian children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2023Article
- Prematurity-associated wheeze: current knowledge and opportunities for further investigation.Pediatric research · 2023Review
- Impaired exercise outcomes with significant bronchodilator responsiveness in children with prematurity-associated obstructive lung disease.Pediatric pulmonology · 2022Article
- Association of early-life factors with prematurity-associated lung disease: prospective cohort study.The European respiratory journal · 2022Article
- Modeling Wheezing Spells Identifies Phenotypes with Different Outcomes and Genetic Associates.American journal of respiratory and critical care medicine · 2022Article
- Late Pre-term Infants with Severe Bronchiolitis and Risk of Asthma by Age 5 Years.The Journal of pediatrics · 2022Article
- Family history of asthma influences outpatient respiratory outcomes in children with BPD.Pediatric pulmonology · 2021Article
- Early Life Factors Associated with Preschool Wheezing in Preterm Infants.Children (Basel, Switzerland) · 2021Article
- The effect of catch-up growth in the first year of life on later wheezing phenotypes.The European respiratory journal · 2020Article
- Predicting Lung Health Trajectories for Survivors of Preterm Birth.Frontiers in pediatrics · 2020Review
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6 authors.
Funding
Abstract
Although respiratory symptoms, including wheezing, are common in preterm-born subjects, the natural history of the wheezing phenotypes and the influence of early-life factors and characteristics on phenotypes are unclear. Participants from the Millennium Cohort Study who were born between 2000 and 2002 were studied at 9 months and at 3, 5, 7, and 11 years. We used data-driven methods to define wheezing phenotypes in preterm-born children and investigated whether the association of early-life factors and characteristics with wheezing phenotypes was similar between preterm- and term-born children. A total of 1,049/1,502 (70%) preterm-born children and 12,307/17,063 (72%) term-born children had recent wheeze data for 3 or 4 time points. Recent wheeze was more common at all time points in the preterm-born group than in term-born group. Four wheezing phenotypes were defined for both groups: no/infrequent, early, persistent, and late. Early-life factors and characteristics, especially antenatal maternal smoking, atopy, and male sex, were associated with increased rates for all phenotypes in both groups, and breastfeeding was protective in both groups, except late wheeze in the preterm group. Preterm-born children had similar phenotypes to term-born children. Although early-life factors and characteristics were similarly associated with the wheezing phenotypes in both groups, the preterm-born group had higher rates of early and persistent wheeze. However, a large proportion of preterm-born children had early wheeze that resolved with time.
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