Evidence map›Paper›PMID 30668631›Full record

Trial reportAnnals of behavioral medicine : a publication of the Society of Behavioral Medicine2019

Effects of Mindfulness-Oriented Recovery Enhancement Versus Social Support on Negative Affective Interference During Inhibitory Control Among Opioid-Treated Chronic Pain Patients: A Pilot Mechanistic Study.

Eric L Garland, Myranda A Bryan, Sarah E Priddy, Michael R Riquino, Brett Froeliger, Matthew O Howard

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Mindfulness-based interventions for substance use disorders.The Cochrane database of systematic reviews · 2021
    Pooled it
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  13. Mindfulness and Behavior Change.Harvard review of psychiatry
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eric L GarlandCollege of Social Work, University of Utah, Salt Lake City, UT, USA.
Myranda A BryanCollege of Social Work, University of Utah, Salt Lake City, UT, USA.
Sarah E PriddyCollege of Social Work, University of Utah, Salt Lake City, UT, USA.
Michael R RiquinoCollege of Social Work, University of Utah, Salt Lake City, UT, USA.
Brett FroeligerDepartment of Neuroscience, Medical University of South Carolina, USA.
Matthew O HowardSchool of Social Work, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Funding

Targeting Hedonic Dysregulation to Address Chronic Pain and Opioid Misuse in Primary Care.R01DA042033 · NIDA · UNIVERSITY OF UTAH · PI GARLAND, ERIC LEE · 2016 to 2020
$2.8M
Effects of Mindfulness-Oriented Intervention on Endogenous Opioid Mechanisms of Hedonic Regulation in Chronic Pain.R61AT009296 · NCCIH · UNIVERSITY OF UTAH · PI GARLAND, ERIC LEE, ZUBIETA, JON-KAR · 2016 to 2017
$831k
Mindfulness-Oriented Recovery Enhancement For Chronic Pain Patients Receiving OpiR03DA032517 · NIDA · FLORIDA STATE UNIVERSITY · PI GARLAND, ERIC LEE · 2011 to 2012
$74k
NCCIH NIH HHS R61 AT009296NIDA NIH HHS R01 DA042033NIDA NIH HHS R03 DA032517
6 · The paper itself

Abstract

backgroundAmong opioid-treated chronic pain patients, deficient response inhibition in the context of emotional distress may contribute to maladaptive pain coping and prescription opioid misuse. Interventions that aim to bolster cognitive control and reduce emotional reactivity (e.g., mindfulness) may remediate response inhibition deficits, with consequent clinical benefits. PURPOSE: To test the hypothesis that a mindfulness-based intervention, Mindfulness-Oriented Recovery Enhancement (MORE), can reduce the impact of clinically relevant, negative affective interference on response inhibition function in an opioid-treated chronic pain sample.

methodsWe examined data from a controlled trial comparing adults with chronic pain and long-term prescription opioid use randomized to either MORE (n = 27) treatment or to an active support group comparison condition (n = 30). Participants completed an Emotional Go/NoGo Task at pre- and post-treatment, which measured response inhibition in neutral and clinically relevant, negative affective contexts (i.e., exposure to pain-related visual stimuli).

resultsRepeated-measures analysis of variance indicated that compared with the support group, participants in MORE evidenced significantly greater reductions from pre- to post-treatment in errors of commission on trials with pain-related distractors relative to trials with neutral distractors, group × time × condition F(1,55) = 4.14, p = .047, η2partial = .07. Mindfulness practice minutes and increased nonreactivity significantly predicted greater emotional response inhibition. A significant inverse association was observed between improvements in emotional response inhibition and treatment-related reductions in pain severity by 3-month follow-up.

conclusionsStudy results provide preliminary evidence that MORE enhances inhibitory control function in the context of negative emotional interference.

Indexed as

Inhibition, PsychologicalSocial SupportAdultAnalgesics, OpioidChronic PainEmotionsExecutive FunctionFemaleHumansMaleMiddle AgedMindfulnessPilot ProjectsPsychomotor PerformanceTreatment OutcomeAnalgesics, OpioidCognitive controlGo/NoGoInhibitory controlMindfulnessOpioidPain

Identifiers

PMID30668631
PMCPMC6735955

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.