ArticlePloS one2019
Feeding intolerance alters the gut microbiota of preterm infants.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- A Randomized, Double-Blind, and Placebo-Controlled Trial of Chinese Herbal Medicine in the Treatment of Childhood Constipation.Clinical and translational gastroenterology · 2021Trial
- Machine Learning-Driven Prediction of Early Enteral Nutrition Intolerance in ICU Patients Using Intra-Abdominal Pressure and Selected Gut Microbial Taxa.Polish journal of microbiology · 2026Article
- Differences in gut microbiota and faecal metabolomics characteristics in preterm infants with feeding intolerance.Journal of medical microbiology · 2026Article
- Observational
- Citrobacter and Acinetobacter are respectively involved in feeding intolerance in preterm infants of different gestational ages: a prospective case-control study.Italian journal of pediatrics · 2025Article
- Negative Healthcare Impacts of Management of Presumed Early-Onset Sepsis in Moderate to Late Preterm Infants on Feeding, Jaundice, and Hospital Length of Stay.Healthcare (Basel, Switzerland) · 2025Article
- Construction and SHAP interpretability analysis of a risk prediction model for feeding intolerance in preterm newborns based on machine learning.BMC medical informatics and decision making · 2024Article
- Reduced Gut Bacterial Diversity in Early Life Predicts Feeding Intolerance in Preterm Neonates.Tropical medicine and infectious disease · 2024Article
- Contemporary use of prophylactic probiotics in NICUs in the United States: a survey update.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Bioelectrical Impedance in Premature Newborns and Its Relationship with Diet Therapy in a Neonatal Intensive Care Unit.Nutrients · 2024Article
- Metabolic and fecal microbial changes in adult fetal growth restricted mice.Pediatric research · 2024Article
- Calorie restriction during gestation impacts maternal and offspring fecal microbiome in mice.Frontiers in endocrinology · 2024Article
- Dynamics and Crosstalk between Gut Microbiota, Metabolome, and Fecal Calprotectin in Very Preterm Infants: Insights into Feeding Intolerance.Nutrients · 2023Article
- Impact of Erythromycin as a Prokinetic on the Gut Microbiome in Children with Feeding Intolerance-A Pilot Study.Antibiotics (Basel, Switzerland) · 2023Article
- A Comparison of Slow Infusion Intermittent Feeding versus Gravity Feeding in Preterm Infants: A Randomized Controlled Trial.Children (Basel, Switzerland) · 2023Article
- The role of Klebsiella populations in preterm infants.Biochemical Society transactions · 2023Review
- Early gut microbiota in very low and extremely low birth weight preterm infants with feeding intolerance: a prospective case-control study.Journal of microbiology (Seoul, Korea) · 2022Observational
- Feeding intolerance.Early human development · 2022Article
- The Impact of Homogenization on Donor Human Milk and Human Milk-Based Fortifiers and Implications for Preterm Infant Health.Current developments in nutrition · 2022Article
- Differences in the Gut Microbiota Composition and Metabolites Associated With Feeding Intolerance in VLBW Infants With a Gestational Age of ≤ 30 Weeks: A Pilot Study.Frontiers in cellular and infection microbiology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Feeding intolerance (FI) is a common disease in preterm infants, often causing a delay in individual development. Gut microbiota play an important role in nutrient absorption and metabolism of preterm infants. To date, few studies have focused on the community composition of gut microbiota of preterm infants with feeding intolerance. In this study, we collected fecal samples from 41 preterm infants diagnosed with feeding intolerance and 29 preterm infants without feeding intolerance, at three specific times during the development and prevalence of feeding intolerance (after birth, when feeding intolerance was diagnosed, after feeding intolerance was gone), from different hospitals for 16S rRNA gene sequencing. The gut microbiota community composition of preterm infants diagnosed with feeding intolerance was significantly different from that of preterm infants without feeding intolerance. At the time when feeding intolerance was diagnosed, the relative abundance of Klebsiella in preterm infants with feeding intolerance increased significantly, and was significantly higher than that of the preterm infants without feeding intolerance. After feeding intolerance was cured, the relative abundance of Klebsiella significantly decreased in the infants diagnosed with feeding intolerance, while the relative abundance of Klebsiella in preterm infants without feeding intolerance was not significantly altered during the development and prevalence of feeding intolerance. Furthermore, we verified that Klebsiella was effective in the diagnosis of feeding intolerance (AUC = 1) in preterm infants, suggesting that Klebsiella is a potential diagnostic biomarker for feeding intolerance.
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Registered trials
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