Evidence map›Paper›PMID 30668209›Full record

ArticleHuman vaccines & immunotherapeutics2019

Invasive pneumococcal disease in relation to vaccine type serotypes.

Paeton L Wantuch, Fikri Y Avci

Abstract readLetterComment
In one paragraph

Article in Human vaccines & immunotherapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Pivotal Phase 3 Randomized Clinical Trial of the Safety, Tolerability, and Immunogenicity of 20-Valent Pneumococcal Conjugate Vaccine in Adults Aged ≥18 Years.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
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  2. Safety, Tolerability, and Immunogenicity of a 20-Valent Pneumococcal Conjugate Vaccine (PCV20) in Adults 60 to 64 Years of Age.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Paeton L Wantucha Department of Biochemistry and Molecular Biology, Center for Molecular Medicine and Complex Carbohydrate Research Center , University of Georgia , Athens , GA , USA.
Fikri Y Avcia Department of Biochemistry and Molecular Biology, Center for Molecular Medicine and Complex Carbohydrate Research Center , University of Georgia , Athens , GA , USA.ORCID 0000-0002-1902-7532

Funding

Glycoscience Training ProgramT32GM107004 · NIGMS · UNIVERSITY OF GEORGIA · PI AMSTER, I JONATHAN, HALTIWANGER, ROBERT S. · 2014 to 2021
$1.3M
NIGMS NIH HHS T32 GM107004
6 · The paper itself

Abstract

Since 1983 the world has been introduced to four vaccines combating disease caused by Streptococcus pneumoniae bacteria. However, despite vaccination programs disease caused by S. pneumoniae continues to lead to high morbidity and mortality worldwide. Surprisingly, instances of invasive pneumococcal disease (IPD) are still highly attributed to serotypes found in the current vaccine, such as serotypes 3 and 19A. Conversely, non-conjugate vaccine serotypes, such as 35B, are increasing and of rising interest. The persistence of vaccine type serotypes and the increase in non-conjugate vaccine type serotypes show the need for further research into conjugate vaccine design and the need for novel strategies to combat IPD. Abbreviation: IPD: invasive pneumococcal disease.

Indexed as

Pneumococcal InfectionsPneumococcal VaccinesHeptavalent Pneumococcal Conjugate VaccineHumansSerogroupStreptococcus pneumoniaeHeptavalent Pneumococcal Conjugate VaccinePneumococcal Vaccinescapsular polysaccharideconjugate vaccinespneumoniaserotype 19Aserotype 3

Identifiers

PMID30668209
PMCPMC6605867

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.