Evidence map›Paper›PMID 30668198›Full record

ArticleLeukemia & lymphoma2019

Second allogeneic hematopoietic cell transplantation for relapse after first allografts.

Boglarka Gyurkocza, Rainer Storb, Thomas R Chauncey, David G Maloney, Barry E Storer, Brenda M Sandmaier

Abstract read
In one paragraph

Article in Leukemia & lymphoma, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Boglarka Gyurkoczaa Department of Medicine , Memorial Sloan Kettering Cancer Center , New York , NY , USA.
Rainer Storbc Clinical Research Division , Fred Hutchinson Cancer Research Center , Seattle , WA , USA.
Thomas R Chaunceyc Clinical Research Division , Fred Hutchinson Cancer Research Center , Seattle , WA , USA.
David G Maloneyc Clinical Research Division , Fred Hutchinson Cancer Research Center , Seattle , WA , USA.
Barry E Storerc Clinical Research Division , Fred Hutchinson Cancer Research Center , Seattle , WA , USA.
Brenda M Sandmaierc Clinical Research Division , Fred Hutchinson Cancer Research Center , Seattle , WA , USA.

Funding

VIRUS-MEDIATED MYELOSUPPRESSIONP01CA018029 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Geoffrey Roger HILL · 1985 to 2026
$128.4M
Project 3: Stem Cell Allografts for Lymphoid MalignanciesP01CA078902 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SANDMAIER, BRENDA MARIE · 1999 to 2025
$46.1M
UNRELATED AND HLA-MISMATCHED RELATED DONOR TRANSPLANTSP01HL036444 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI RAWLINGS, DAVID J · 1986 to 2010
$25.9M
Project 3: Gene Therapy for Correction of Blood DisordersP01HL122173 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KIEM, HANS-PETER · 2015 to 2019
$12.9M
NCI NIH HHS P01 CA018029NCI NIH HHS P01 CA078902NHLBI NIH HHS P01 HL036444NHLBI NIH HHS P01 HL122173
6 · The paper itself

Abstract

We analyzed outcomes of 126 patients with hematologic malignancies, who relapsed after first allogeneic hematopoietic cell transplantation (HCT) and received subsequent allografts. In 17 cases, the original donors were utilized, while in 109 cases different donors were identified. The 2-year overall survival (OS), relapse, and non-relapse mortality (NRM) rates were 33%, 42%, and 33%, respectively. Patients with early relapse after first allogeneic HCT (within 100 days vs. 100 days to 12 months vs. >12 months) had higher relapse rates (50% vs. 47% vs. 34%, respectively;

Indexed as

AdolescentAdultAgedChildChild, PreschoolFemaleFollow-Up StudiesGraft vs Host DiseaseHematologic NeoplasmsHematopoietic Stem Cell TransplantationHumansIncidenceMaleMiddle AgedNeoplasm Recurrence, LocalNew YorkAllogeneic hematopoietic cell transplantationpost-transplant relapsesecond allotransplant

Identifiers

PMID30668198
PMCPMC6594865

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.